Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2022 Dec;240:154223. doi: 10.1016/j.prp.2022.154223. Epub 2022 Nov 15.
PCGEM1 Prostate-Specific Transcript is an lncRNA participating in the carcinogenesis process in different tissues. The gene coding this lncRNA is located on chr2:192,749,008-192,783,952 (GRCh38/hg38), plus strand and has 34,945 bases. In addition to prostate cancer, it has been shown to influence progression of cervical, endometrial, gastric, ovarian, hepatocellular and renal cancers. Functionally, PCGEM1 regulates activity of a number of molecular axes, namely miR-642a-5p/LGMN, miR-182/FBXW11, miR-129-5p/STAT3, miR-129-5p/P4HA2, miR-433-3p/FGF2, miR-539-5p/CDK6, miR-129-5p/ETV1, miR-433-3p/WTAP, miR-590-3p/SOX11 and miR-506-3p/TRIAP1. Moreover, it has a regulatory effect on RhoA, NF-κB and β-catenin/TCF signaling pathways. We have designed this literature search to collect all relevant data about the function of PCGEM1 in the carcinogenesis.
PCGEM1 前列腺特异性转录物是一种参与不同组织癌变过程的 lncRNA。该 lncRNA 的编码基因位于 chr2:192,749,008-192,783,952（GRCh38/hg38），正链，有 34945 个碱基。除了前列腺癌，它还被证明会影响宫颈癌、子宫内膜癌、胃癌、卵巢癌、肝癌和肾癌的进展。在功能上，PCGEM1 调节多个分子轴的活性，即 miR-642a-5p/LGMN、miR-182/FBXW11、miR-129-5p/STAT3、miR-129-5p/P4HA2、miR-433-3p/FGF2、miR-539-5p/CDK6、miR-129-5p/ETV1、miR-433-3p/WTAP、miR-590-3p/SOX11 和 miR-506-3p/TRIAP1。此外，它对 RhoA、NF-κB 和 β-catenin/TCF 信号通路有调节作用。我们设计了本次文献检索，以收集关于 PCGEM1 在癌变过程中功能的所有相关数据。
