Gorelick Philip B
Section of Stroke and Neurocritical Care, Davee Department of Neurology, Northwestern University Feinberg School of Medicine, 625 North Michigan Avenue Suite 1150, Chicago, IL 60611, USA.
Clin Geriatr Med. 2023 Feb;39(1):67-76. doi: 10.1016/j.cger.2022.08.001. Epub 2022 Oct 18.
The Maintenance of brain health is a lifelong process whereby potentially deleterious exposures such as cardiovascular risks, amyloid beta, and phosphorylated tau may adversely affect the brain decades before there are clinical manifestations. Thus, the early structural and neuropathological foundation for the development of cognitive impairment and its allied features later in life may provide precursor targets such that interventions may be applied to prevent or slow cognitively impairing processes if the underlying mechanism(s) can be addressed in time.
大脑健康的维持是一个终身过程，在此过程中，诸如心血管风险、β-淀粉样蛋白和磷酸化tau蛋白等潜在有害暴露可能在出现临床表现的数十年前就对大脑产生不利影响。因此，认知障碍及其相关特征在生命后期发展的早期结构和神经病理学基础可能提供前驱靶点，以便在潜在机制能够及时得到解决的情况下，可以采取干预措施来预防或减缓认知损害过程。
