人类通过 pIKK 来跳过 NLRP3 与 NEK7 的结合。
Humans pIKK-up NLRP3 to skip NEK7.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Trends Immunol. 2022 Dec;43(12):947-949. doi: 10.1016/j.it.2022.10.007. Epub 2022 Nov 17.
NLRP3 inflammasome regulation is essential for controlling cell death and inflammation. Mechanistic studies in murine cells suggest a two-step model of priming and activation with an indispensable role for NEK7. However, in a recent article in Immunity, Schmacke et al. report that, in humans, transcription-independent NLRP3 activation occurs by circumventing NEK7 via IKKβ.
NLRP3 炎性小体的调节对于控制细胞死亡和炎症至关重要。在小鼠细胞中的机制研究表明，存在一个两步的预激活和激活模型，其中 NEK7 起着不可或缺的作用。然而，在最近发表在《Immunity》上的一篇文章中，Schmacke 等人报道，在人类中，通过绕过 NEK7 利用 IKKβ，可发生非转录依赖性 NLRP3 激活。
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