婴幼儿血管瘤溃疡的发生率及相关临床因素。

Incidence and clinical factors associated with ulceration in infantile hemangiomas.

机构信息

Division of Dermatology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio.

Department of Dermatology, University of California, San Francisco School of Medicine, San Francisco, California; Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

出版信息

J Am Acad Dermatol. 2023 Feb;88(2):414-420. doi: 10.1016/j.jaad.2022.10.047. Epub 2022 Oct 28.

DOI:10.1016/j.jaad.2022.10.047

PMID:36404484

Abstract

BACKGROUND

Ulceration is an important complication in infantile hemangiomas (IHs). Prior to the use of β-blockers, the estimated incidence of this complication in a referral population was between 15% and 30%. The incidence and factors associated with ulceration have not been systematically studied since the emergence of β-blocker therapy.

OBJECTIVE

Examine the incidence and clinical predictors for ulceration in IHs.

METHODS

Retrospective study at tertiary referral centers.

RESULTS

Compared with a previous large pre-propranolol cohort study, ulceration occurred at a significantly lower incidence of 11.4%. Clinical factors associated with ulceration included partial segmental morphology, location in the diaper area, and size greater than 5 cm. Higher risk of ulceration in Black patients was observed, suggesting barriers to care including delayed diagnosis and referral to specialty care.

LIMITATIONS

Retrospective design at tertiary referral centers.

CONCLUSION

Compared with reports before the use of β-blockers became widespread, the incidence of ulceration in IHs has decreased. However, it continues to be a relatively frequent complication of IH.

摘要