Src 激酶调节葡萄糖代谢在癌症中的强大作用。

The potent role of Src kinase-regulating glucose metabolism in cancer.

机构信息

The First Affiliated Hospital, Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China.

出版信息

Biochem Pharmacol. 2022 Dec;206:115333. doi: 10.1016/j.bcp.2022.115333. Epub 2022 Oct 29.

DOI:10.1016/j.bcp.2022.115333

PMID:36404485

Abstract

Src kinase is a membrane-related nonreceptor tyrosine kinase that plays an essential role in cell growth, division, migration, and survival signaling pathways. In addition, it regulates glucose metabolism in cancer cells through different mechanisms, such as directly regulating glucose metabolism related enzymes and glucose transporters or indirectly regulating transcription factors and signal transduction pathways. In this review, we clarify the role of Src kinase in regulating glucose metabolism in cancer cells, and partially explain the pathogenesis of malignant tumors. We also discuss that further understanding and study of the role of Src kinase in glucose metabolism will provide a potential therapeutic window for cancer treatment.

摘要

Src 激酶是一种与膜相关的非受体酪氨酸激酶，在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用。此外，它通过不同的机制调节癌细胞中的葡萄糖代谢，例如直接调节葡萄糖代谢相关酶和葡萄糖转运体，或间接调节转录因子和信号转导途径。在这篇综述中，我们阐明了 Src 激酶在调节癌细胞葡萄糖代谢中的作用，并部分解释了恶性肿瘤的发病机制。我们还讨论了进一步了解和研究 Src 激酶在葡萄糖代谢中的作用将为癌症治疗提供一个潜在的治疗窗口。