与二甲双胍和依那普利联合使用对链脲佐菌素诱导的大鼠糖尿病肾病的影响。 （注：原文中“Effect of and in combination with”表述有误，推测可能是“Effect of [某物质] and in combination with”，这里按纠正后的意思翻译）
Effect of and in combination with Metformin and Enalapril in streptozotocin induced diabetic nephropathy in rats.
作者信息
Sanaye Mrinal, Sathyapal Greeshma, Kulkarni Yogesh A
机构信息
Department of Pharmacology and Toxicology, Prin. K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai, 400005 India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, 400056 India.
出版信息
J Diabetes Metab Disord. 2022 Jul 18;21(2):1349-1358. doi: 10.1007/s40200-022-01065-5. eCollection 2022 Dec.
AIM
The present study was designed to investigate the effect of methanolic extract of (MECP) and in combination with drugs (Metformin and Enalapril) used in clinical practice in streptozotocin (STZ) induced diabetic nephropathy (DN) in rats.
METHODS
Diabetes was induced in male Wistar rats by a single injection of STZ (50 mg/kg ). After 28 days diabetic rats were divided into six groups. Two groups were treated with MECP (200 mg/kg .), MECP (400 mg/kg .) respectively; one group was treated with metformin (225 mg/kg), enalapril (3.2 mg/kg) combination; and two groups were treated with a combination of metformin, enalapril and MECP (200 mg/kg) and combination of metformin, enalapril and MECP (400 mg/kg) respectively. One group was kept as diabetic control. At the end of the study, body weight, kidney weight, and kidney hypertrophy index were evaluated. Biochemical and antioxidant parameters were evaluated. TGF-β levels in serum were estimated. Histopathology of the kidney was also studied.
RESULTS
The combination therapy showed a significant increase in the body weight, lowered blood glucose levels and ameliorated kidney hypertrophy index in STZ induced diabetic nephropathy in rats. It also normalized the altered levels of serum and urine parameters. Histopathological evaluation revealed that combination therapy reduced the vacuolar degeneration of tubules.
CONCLUSIONS
The results indicate that combination therapy of metformin, enalapril, and MECP has beneficial effects in management of diabetic nephropathy.
目的
本研究旨在探讨[植物名称]甲醇提取物（MECP）以及其与临床实践中使用的药物（二甲双胍和依那普利）联合应用对链脲佐菌素（STZ）诱导的大鼠糖尿病肾病（DN）的影响。
方法
通过单次注射STZ（50mg/kg）诱导雄性Wistar大鼠患糖尿病。28天后，将糖尿病大鼠分为六组。两组分别用MECP（200mg/kg）、MECP（400mg/kg）治疗；一组用二甲双胍（225mg/kg）、依那普利（3.2mg/kg）联合治疗；两组分别用二甲双胍、依那普利与MECP（200mg/kg）的组合以及二甲双胍、依那普利与MECP（400mg/kg）的组合治疗。一组作为糖尿病对照组。在研究结束时，评估体重、肾脏重量和肾脏肥大指数。评估生化和抗氧化参数。估计血清中的转化生长因子-β水平。还研究了肾脏的组织病理学。
结果
联合治疗使链脲佐菌素诱导的大鼠糖尿病肾病模型的体重显著增加，血糖水平降低，并改善了肾脏肥大指数。它还使血清和尿液参数的改变水平恢复正常。组织病理学评估显示联合治疗减少了肾小管的空泡变性。
结论
结果表明，二甲双胍、依那普利和MECP联合治疗对糖尿病肾病的管理具有有益作用。
需注意，原文中“(MECP)”括号内应该是具体植物名称，但未给出，这里保留了原文格式。
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