真性红细胞增多症所致微小病变病：一例报告
Minimal change disease caused by polycythemia vera: A case report.
作者信息
Xu Li, Lu Li-Li, Gao Jian-Dong
机构信息
Department of Nephrology, Shuguang Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (20DZ2272200), Shanghai 201203, China.
出版信息
World J Clin Cases. 2022 Nov 16;10(32):11993-11999. doi: 10.12998/wjcc.v10.i32.11993.
BACKGROUND
Polycythemia vera (PV), often attributed to the JAK2 V617F mutation, is characterized by enhanced red blood cell counts in the peripheral blood. PV-associated renal disease is clinically rare; to date, there have been reports of other chronic kidney diseases related to PV, but no reports on PV-associated minimal change disease.
CASE SUMMARY
A 37-year-old man presented with proteinuria and high red blood cell count on January 4, 2021. The patient underwent bone marrow and renal biopsies, then was subsequently diagnosed with PV and minimal change in disease. Hydroxyurea was administered and proteinuria remission was achieved. The patient's last visit was on April 14, 2022.
CONCLUSION
We inferred that there may be a causal relationship between PV and minimal change disease.
背景
真性红细胞增多症（PV）通常归因于JAK2 V617F突变，其特征是外周血中红细胞计数增加。PV相关的肾脏疾病在临床上较为罕见；迄今为止，已有与PV相关的其他慢性肾脏疾病的报道，但尚无关于PV相关微小病变病的报道。
病例摘要
一名37岁男性于2021年1月4日出现蛋白尿和红细胞计数升高。患者接受了骨髓和肾脏活检，随后被诊断为PV和微小病变病。给予羟基脲治疗后蛋白尿缓解。患者最后一次就诊时间为2022年4月14日。
结论
我们推断PV与微小病变病之间可能存在因果关系。
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