与癌症、化疗和造血干细胞移植相关的肾小球疾病。
Glomerular diseases associated with cancer, chemotherapy, and hematopoietic stem cell transplantation.
机构信息
Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
Division of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY; Department of Pathology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY; Division of Nephrology, Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
出版信息
Adv Chronic Kidney Dis. 2014 Jan;21(1):48-55. doi: 10.1053/j.ackd.2013.08.003.
Many solid and hematological malignancies have been associated with different glomerular diseases. Several case reports and case series of cancer-associated glomerular diseases have shown that treating the cancer may lead to resolution of the glomerular process. Hence, knowledge and approach to cancer-associated glomerular diseases is important for both the caring nephrologists and the cancer specialists. While membranous nephropathy has been classically associated with solid malignancies, minimal change disease has been commonly described with hematologic malignancies, especially non-Hodgkin's lymphoma. Membranoproliferative glomerulonephritis is increasingly being recognized to be associated with chronic hematologic malignancies such as chronic lymphocytic leukemia. In this article, we review various cancer-associated glomerular diseases and their pathogenesis as well as principles of treatment. In addition, we also review glomerular diseases seen after chemotherapy and hematopoietic stem cell transplantation.
许多实体瘤和血液系统恶性肿瘤与不同的肾小球疾病相关。一些癌症相关性肾小球疾病的病例报告和病例系列研究表明，治疗癌症可能导致肾小球过程的缓解。因此，癌症相关性肾小球疾病的知识和方法对于肾脏病医生和癌症专家都很重要。虽然膜性肾病通常与实体瘤相关，微小病变性肾病通常与血液系统恶性肿瘤相关，尤其是非霍奇金淋巴瘤。膜增殖性肾小球肾炎也越来越多地与慢性血液系统恶性肿瘤如慢性淋巴细胞白血病相关。本文回顾了各种癌症相关性肾小球疾病及其发病机制和治疗原则。此外，我们还回顾了化疗和造血干细胞移植后出现的肾小球疾病。
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