M'harzi Soulaimane, Elouali Aziza, Lahrache Karim, Ghanam Ayad, Babakhouya Abdeladim, Rkain Maria, Benajiba Noufissa
Faculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco.
Department of Pediatrics, Mohammed VI University Hospital of Oujda, Morocco.
Leuk Res Rep. 2022 Nov 9;18:100357. doi: 10.1016/j.lrr.2022.100357. eCollection 2022.
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25-30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, it can cause various adverse effects, including acute pancreatitis (AP). Recently, an increase in the number of pediatric AP cases following L-Asparaginase in Acute Lymphoblastic Leukemia been reported. We presented a case of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations.
急性淋巴细胞白血病（ALL）是儿童中最常见的恶性肿瘤，占所有儿童恶性肿瘤的25%-30%。尽管由于化疗进展治疗结果有所改善，但仍有一组患者会经历严重不良事件。L-天冬酰胺酶是ALL化疗中使用的一种有效抗肿瘤药物。尽管其适应证明确，但它可引起各种不良反应，包括急性胰腺炎（AP）。最近，有报道称急性淋巴细胞白血病患者使用L-天冬酰胺酶后儿科AP病例数有所增加。我们报告了1例因使用L-天冬酰胺酶制剂诱发ALL患儿急性胰腺炎的病例。
