Acosta-España Jaime David, Voigt Kerstin
Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Institute of Microbiology, Friedrich Schiller University Jena, Jena, Germany.
Front Microbiol. 2022 Nov 3;13:1035100. doi: 10.3389/fmicb.2022.1035100. eCollection 2022.
Fungal diseases were underestimated for many years. And the global burden of fungal infections is substantial and has increased in recent years. Invasive fungal infections have been linked to several risk factors in humans which basically depend on the individual homeostasis of the patients. However, many fungi can infect even apparently healthy people. Knowledge of these pathogens is critical in reducing or stopping morbidity and/or mortality statistics due to fungal pathogens. Successful therapeutic strategies rely on rapid diagnosis of the causative fungal agent and the underlying disease. However, the terminology of the diseases was updated to existing phylogenetic classifications and led to confusion in the definition of mucormycosis, conidiobolomycosis, and basidiobolomycosis, which were previously grouped under the now-uncommon term zygomycosis. Therefore, the ecological, taxonomic, clinical, and diagnostic differences are addressed to optimize the understanding and definition of these diseases. The term "coenocytic hyphomycosis" is proposed to summarize all fungal infections caused by and species of and .
多年来，真菌疾病一直被低估。真菌感染的全球负担相当大，且近年来有所增加。侵袭性真菌感染与人类的多种风险因素有关，这些因素基本上取决于患者的个体内环境稳定。然而，许多真菌甚至可以感染看似健康的人。了解这些病原体对于减少或阻止真菌病原体导致的发病率和/或死亡率统计数据至关重要。成功的治疗策略依赖于对致病真菌病原体和潜在疾病的快速诊断。然而，疾病的术语已根据现有的系统发育分类进行了更新，这导致了毛霉病、耳霉病和蛙粪霉病定义上的混乱，这些疾病以前被归在现已不常用的术语接合菌病之下。因此，本文讨论了生态、分类、临床和诊断方面的差异，以优化对这些疾病的理解和定义。提出了“多核丝孢菌病”这一术语，以概括由 和 的 及 物种引起的所有真菌感染。
