Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Transpl Int. 2022 Nov 2;35:10754. doi: 10.3389/ti.2022.10754. eCollection 2022.
Urinary tract infection (UTI) occurs in 25% of recipients of living-donor kidney transplantation (LDKT). Female sex, age, and anatomical abnormalities have been reported as recipient-related risk factors for UTI after LDKT; few studies have reported donor-related factors. We retrospectively examined UTI occurrence within 5 years of transplantation in recipients ( = 211) who underwent LDKT at our hospital between April 2011 and April 2021. All nephrectomies were performed using a retroperitoneal pure laparoscopic approach. The ureter was dissected at the lower level of the common iliac artery and trimmed to the shortest length, enough to reach the bladder using extra vesicular ureterocystoneostomy with a 3 cm submucosal tunnel. Twenty-nine recipients (13.7%) developed UTI within 5 years, and the median time to onset was 40.0 days. After adjusting for the well-known factors, including recipient sex, graft ureter length was an independent factor for UTI occurrence (HR 1.25, 95% CI 1.02∼1.53, = 0.028) in the multivariate Cox regression analysis. The long ureter is usually trimmed, and the widest part is used for anastomosis, which may increase the possibility of reflux from the bladder to the ureter in the standard technique. The ureter length may be associated with the incidence of UTI after LDKT.
尿路感染 (UTI) 发生在 25% 的活体供肾移植 (LDKT) 受者中。女性、年龄和解剖异常已被报道为 LDKT 后 UTI 的受者相关危险因素;很少有研究报道供者相关因素。我们回顾性分析了 2011 年 4 月至 2021 年 4 月期间在我院接受 LDKT 的 211 例受者在移植后 5 年内 UTI 的发生情况。所有肾切除术均采用经腹膜后纯腹腔镜入路进行。输尿管在髂总动脉下方低位解剖,并修剪至最短长度,足以通过额外的囊外输尿管膀胱吻合术用 3cm 的黏膜下隧道到达膀胱。29 例(13.7%)受者在 5 年内发生 UTI,发病中位时间为 40.0 天。在调整了包括受者性别在内的已知因素后,多变量 Cox 回归分析显示,移植肾输尿管长度是 UTI 发生的独立因素(HR 1.25,95%CI 1.02∼1.53, = 0.028)。长输尿管通常被修剪,最宽的部分用于吻合,这可能会增加标准技术中膀胱反流到输尿管的可能性。输尿管长度可能与 LDKT 后 UTI 的发生率有关。