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雌激素诱导的垂体肿瘤中腺激肽释放酶升高。

Elevated glandular kallikrein in estrogen-induced pituitary tumors.

作者信息

Powers C A

出版信息

Endocrinology. 1987 Jan;120(1):429-31. doi: 10.1210/endo-120-1-429.

DOI:10.1210/endo-120-1-429
PMID:3640707
Abstract

Anterior pituitary tumors were induced in F344 rats by implants of diethylstilbesterol (DES) for 8 weeks. DES-induced tumors contained 250 times more glandular kallikrein than anterior pituitaries from rats not exposed to estrogen, and 6.6 times more glandular kallikrein than anterior pituitaries from rats exposed to large doses of estrogen for 10 days. DES-induced anterior pituitary tumors in F344 rats arise from lactotroph proliferation. Thus, the results suggest that anterior pituitary glandular kallikrein is associated with lactotrophs.

摘要

通过植入己烯雌酚（DES）8周诱导F344大鼠发生垂体前叶肿瘤。DES诱导的肿瘤所含的腺体激肽释放酶比未接触雌激素的大鼠垂体前叶多250倍，比接触大剂量雌激素10天的大鼠垂体前叶多6.6倍。F344大鼠中DES诱导的垂体前叶肿瘤源于催乳素细胞增殖。因此，结果表明垂体前叶腺体激肽释放酶与催乳素细胞有关。

相似文献

1
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Biol Reprod. 1988 May;38(4):846-52. doi: 10.1095/biolreprod38.4.846.

引用本文的文献

1
Global analysis of gene expression in the estrogen induced pituitary tumor of the F344 rat.F344大鼠雌激素诱导性垂体肿瘤中基因表达的全局分析。
J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):188-96. doi: 10.1016/j.jsbmb.2006.06.025. Epub 2006 Sep 26.
2
Cellular mechanisms of estrogen- and dopamine-induced control of glandular kallikrein in the anterior pituitary of the rat.雌激素和多巴胺诱导大鼠垂体前叶腺激肽释放酶调控的细胞机制
Cell Tissue Res. 1993 Dec;274(3):421-7. doi: 10.1007/BF00314538.