Department of Obstetrics and Gynaecology, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Afr Health Sci. 2022 Jun;22(2):475-479. doi: 10.4314/ahs.v22i2.55.
The purpose of this present study to investigate the lipid profile levels and basal body mass index in preeclampsia and normal pregnancy in Bangladeshi women.
This case-control study was conducted at Sheba Hospital Kaligonj Bangladesh with 70 participants among 35 normal pregnancy (control) and 35 preeclampsia women (case) were enrolled from August 2018 to July 2019. Blood samples were obtained for analysis of total cholesterol, triglyceride and high-density lipoprotein by enzymatic assays and low-density lipoprotein by using Fried Ewald's formula in between 22-36 weeks of gestation.
This study found the mean age of preeclampsia and normal pregnancy women were 24.71±2.56 and 23.09±2.1 respectively with significant (P= 0.005). Basal body mass index, total cholesterol, triglyceride and low-density lipoprotein significantly higher (P=0.002), (P= 0.000), (P= 0.022) and (P=0.000) in preeclampsia compared to normal pregnancy respectively. While high-density lipoprotein comparatively lower in preeclampsia than normal pregnancy and consider significant as (P=0.037).
Abnormal lipid profile and increased body mass index is contributed to the development of preeclampsia. The frequent antenatal monitoring of lipid profiles provides the status which helps to require management and reduces the preeclampsia which enhances maternal and fetal wellbeing and fetal outcome.
本研究旨在探讨孟加拉国妇女子痫前期和正常妊娠的血脂水平和基础体重指数。
本病例对照研究在孟加拉国 Kaligonj 的 Sheba 医院进行，共有 70 名参与者，其中 35 名正常妊娠（对照组）和 35 名子痫前期妇女（病例组）于 2018 年 8 月至 2019 年 7 月入组。在 22-36 周妊娠期间，采集血样用于分析总胆固醇、甘油三酯和高密度脂蛋白，通过酶法，低密度脂蛋白则通过 Fried Ewald 公式进行分析。
本研究发现，子痫前期和正常妊娠妇女的平均年龄分别为 24.71±2.56 和 23.09±2.1，差异具有统计学意义（P=0.005）。基础体重指数、总胆固醇、甘油三酯和低密度脂蛋白在子痫前期中明显更高（P=0.002）、（P=0.000）、（P=0.022）和（P=0.000），而高密度脂蛋白在子痫前期中则较低，差异具有统计学意义（P=0.037）。
异常的血脂谱和体重指数增加是子痫前期发展的原因。频繁的产前血脂谱监测可以提供相关状态，有助于进行管理，从而降低子痫前期的发生，提高母婴健康和胎儿结局。
