Miao Runran, Wang Libo, Chen Zhigang, Ge Shiqi, Li Li, Zhang Kai, Chen Yingen, Guo Wenjing, Duan Xulei, Zhu Mingyang, Zhao Guoan, Lin Fei
Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Heart Center of Xinxiang Medical University, Xinxiang, China.
College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Front Cardiovasc Med. 2022 Nov 3;9:1000578. doi: 10.3389/fcvm.2022.1000578. eCollection 2022.
Myocardial remodeling is a key pathophysiological basis of heart failure, which seriously threatens human health and causes a severe economic burden worldwide. During chronic stress, the heart undergoes myocardial remodeling, mainly manifested by cardiomyocyte hypertrophy, apoptosis, interstitial fibrosis, chamber enlargement, and cardiac dysfunction. The NADPH oxidase family (NOXs) are multisubunit transmembrane enzyme complexes involved in the generation of redox signals. Studies have shown that NOXs are highly expressed in the heart and are involved in the pathological development process of myocardial remodeling, which influences the development of heart failure. This review summarizes the progress of research on the pathophysiological processes related to the regulation of myocardial remodeling by NOXs, suggesting that NOXs-dependent regulatory mechanisms of myocardial remodeling are promising new therapeutic targets for the treatment of heart failure.
心肌重构是心力衰竭的关键病理生理基础，严重威胁人类健康并在全球造成沉重的经济负担。在慢性应激过程中，心脏会发生心肌重构，主要表现为心肌细胞肥大、凋亡、间质纤维化、心腔扩大和心脏功能障碍。NADPH氧化酶家族（NOXs）是参与氧化还原信号产生的多亚基跨膜酶复合物。研究表明，NOXs在心脏中高度表达，并参与心肌重构的病理发展过程，影响心力衰竭的发生发展。本文综述了NOXs对心肌重构调节相关病理生理过程的研究进展，提示NOXs依赖的心肌重构调节机制有望成为治疗心力衰竭的新治疗靶点。
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