Shi Xiaomeng, Dorsey Arin, Qiu Hongyu
Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA.
Antioxidants (Basel). 2022 Apr 29;11(5):877. doi: 10.3390/antiox11050877.
Chronic pressure overload is a key risk factor for mortality due to its subsequent development of heart failure, in which the underlying molecular mechanisms remain vastly undetermined. In this review, we updated the latest advancements for investigating the role and relevant mechanisms of oxidative stress involved in the pathogenesis of pressure-overload-induced cardiomyopathy and cardiac dysfunction, focusing on significant biological sources of reactive oxygen species (free radical) production, antioxidant defenses, and their association with the cardiac metabolic remodeling in the stressed heart. We also summarize the newly developed preclinical therapeutic approaches in animal models for pressure-overload-induced myocardial damage. This review aims to enhance the current understanding of the mechanisms of chronic hypertensive heart failure and potentially improve the development of better therapeutic strategies for the associated diseases.
慢性压力超负荷是导致心力衰竭死亡的关键风险因素，但其潜在的分子机制仍未明确。在本综述中，我们更新了关于氧化应激在压力超负荷诱导的心肌病和心脏功能障碍发病机制中的作用及相关机制的最新研究进展，重点关注活性氧（自由基）产生的重要生物学来源、抗氧化防御及其与应激心脏中心脏代谢重塑的关联。我们还总结了在动物模型中针对压力超负荷诱导的心肌损伤新开发的临床前治疗方法。本综述旨在加深对慢性高血压性心力衰竭机制的当前理解，并可能改善相关疾病更好治疗策略的开发。
