Luo Dan, Liu Li, Zhang Hai-Ming, Zhou Yu-Dian, Zhou Min-Feng, Li Jin-Xiao, Yu Zhao-Min, Chen Rui, Liang Feng-Xia
Department of Acupuncture and Moxibustion, Hubei University of Traditional Chinese Medicine, Wuhan, China.
Department of Respiratory, Wuhan No. 1 Hospital, Wuhan, China.
Front Mol Neurosci. 2022 Nov 3;15:817738. doi: 10.3389/fnmol.2022.817738. eCollection 2022.
Acupuncture is a common complementary and alternative therapy around the world, but its mechanism remains still unclear. In the past decade, some studies indicated that transient receptor potential vanilloid (TRPV) channels play a great role in the response of acupuncture stimulation. In this article, we discussed the relationship between acupuncture and TRPV channels. Different from inhibitors and agonists, the regulation of acupuncture on TRPV channels is multi-targeted and biphasic control. Acupuncture stimulation shows significant modulation on TRPV1 and TRPV4 at the autonomic nervous system (ANS) including central and peripheral nervous systems. On the contrary, the abundant expression and functional participation of TRPV1 and TRPV4 were specific to acupuncture stimulation at acupoints. The enhancement or inhibition of TRPV channels at different anatomical levels will affect the therapeutic effect of acupuncture. In conclusion, TRPV channels help to understand the principle of acupuncture stimulation, and acupuncture also provides a potential approach to TRPV-related trials.
针灸是一种在世界各地普遍使用的补充和替代疗法，但其机制仍不清楚。在过去十年中，一些研究表明，瞬时受体电位香草酸（TRPV）通道在针刺刺激反应中起重要作用。在本文中，我们讨论了针灸与TRPV通道之间的关系。与抑制剂和激动剂不同，针灸对TRPV通道的调节是多靶点和双相控制的。针刺刺激在包括中枢和外周神经系统在内的自主神经系统（ANS）中对TRPV1和TRPV4有显著调节作用。相反，TRPV1和TRPV4的丰富表达和功能参与是穴位针刺刺激所特有的。不同解剖水平上TRPV通道的增强或抑制会影响针灸的治疗效果。总之，TRPV通道有助于理解针刺刺激的原理，针灸也为TRPV相关试验提供了一种潜在方法。
