Department of Nursing, School of Nursing, University of Phayao, Phayao, Thailand.
Division of Social and Administration Pharmacy, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
Front Public Health. 2022 Nov 3;10:962809. doi: 10.3389/fpubh.2022.962809. eCollection 2022.
Tuberculosis (TB) is one of the major public health issues in every country. Alcohol consumption is one of the reasons associated with the severity of symptoms and death among TB patients. The impact of alcohol use on TB relapse outcomes is still debatable. This study aimed to conduct a systematic review and meta-analysis (SR/MA) to find the link between alcohol use and TB relapse outcomes.
Data collection was performed from December 2021 to March 2022; and was obtained from electronic databases including CINAHL, PubMed, and Scopus. The researcher carefully searched and reviewed all the relevant research concerning drinking alcohol and relapse outcomes among TB patients. A set of inclusion and exclusion criteria was used to assess research publications. The methodological quality of eligible publications was assessed using the Newcastle-Ottawa Scale. Random meta-analysis was used to determine odds ratios (ORs) with a 95% confidence interval (CIs). The funnel plot, Begg's test, and Egger's test were employed to investigate publication bias.
There were a total of 2,113 studies found and reviewed, and eight publications were chosen for the analysis. It was found that among TB patients with a moderate appearance of heterogeneity, drinking alcohol increases the probability of relapse (OR = 3.64; 95% CI: 2.26-5.88, < 0.001) and mortality (OR = 1.72; 95% CI: 1.40-2.12, < 0.001). The funnel plot, Begg's test, and Egger's test all revealed that there was no indication of publication bias.
Relapses and mortality among tuberculosis patients are considerably increased by alcohol drinking. More research into the causality of this link between the degree of alcohol use and the underlying processes is required.
PROSPERO [CRD 42022295865].
结核病（TB）是每个国家的主要公共卫生问题之一。饮酒是与结核病患者症状严重程度和死亡相关的原因之一。饮酒对结核病复发结局的影响仍存在争议。本研究旨在进行系统评价和荟萃分析（SR/MA），以发现饮酒与结核病复发结局之间的联系。
数据收集于 2021 年 12 月至 2022 年 3 月进行，来自 CINAHL、PubMed 和 Scopus 等电子数据库。研究人员仔细搜索并审查了所有关于饮酒和结核病患者复发结局的相关研究。使用一套纳入和排除标准来评估研究出版物。使用纽卡斯尔-渥太华量表评估合格出版物的方法学质量。使用随机荟萃分析确定比值比（ORs）和 95%置信区间（CIs）。使用漏斗图、贝格检验和埃格检验来评估发表偏倚。
共发现并审查了 2113 项研究，选择了 8 项出版物进行分析。结果表明，在中等异质性的结核病患者中，饮酒会增加复发的可能性（OR=3.64；95%CI：2.26-5.88，<0.001）和死亡率（OR=1.72；95%CI：1.40-2.12，<0.001）。漏斗图、贝格检验和埃格检验均表明不存在发表偏倚的迹象。
饮酒会显著增加结核病患者的复发和死亡。需要进一步研究饮酒程度与潜在过程之间的这种联系的因果关系。
PROSPERO [CRD 42022295865]。
