尼日利亚耐多药肺结核（MDR-TB）患者及其非结核病家庭接触者的酒精使用障碍。
Alcohol use disorders in multidrug resistant tuberculosis (MDR-TB) patients and their non-tuberculosis family contacts in Nigeria.
机构信息
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
出版信息
Pan Afr Med J. 2020 Aug 21;36:321. doi: 10.11604/pamj.2020.36.321.17118. eCollection 2020.
INTRODUCTION
the main aim of this study was to determine the prevalence and associated factors of alcohol use disorder (AUD) in patients with Multi-Drug Treatment-Resistant Tuberculosis (MDR-TB) compared with their non-tuberculosis control, and its association with disease pattern and associated medical comorbidities.
METHODS
MDR-TB patients (128) and their respective caregivers were interviewed in a treatment unit in Nigeria. Diagnosis of AUD was made using the Structured Clinical Interview for DSM-IV Axis I Disorder, information was obtained on the severity of the TB and associated health problems.
RESULTS
prevalence of AUD was (21.9%) and was significantly higher among cases than in controls (2.3%), p = 0.006. Severe TB, OR = 3.33 (1.56-6.83), hematological diseases, OR = 2.34 (1.06-4.33) and HIV/AIDS, OR = 3.01 (1.67-7.01) were the strongest predictors of AUD at 95% CI. AUD was highly prevalent in MDR-TB and was associated with certain medical comorbidities and increased severity of the illness.
简介
本研究的主要目的是确定与未患有结核病的对照相比，多重耐药结核病（MDR-TB）患者中酒精使用障碍（AUD）的患病率及其相关因素，以及其与疾病模式和相关合并症的关联。
方法
在尼日利亚的一个治疗单位对 MDR-TB 患者（128 人）及其各自的照顾者进行了访谈。使用DSM-IV 轴 I 障碍的结构化临床访谈对 AUD 进行诊断，收集了有关结核病严重程度和相关健康问题的信息。
结果
AUD 的患病率为（21.9%），病例组明显高于对照组（2.3%），p=0.006。严重的结核病，OR=3.33（1.56-6.83），血液疾病，OR=2.34（1.06-4.33）和 HIV/AIDS，OR=3.01（1.67-7.01）是 AUD 在 95%CI 中最强的预测因素。AUD 在 MDR-TB 中患病率很高，与某些合并症和疾病严重程度增加有关。
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