长期低剂量接触剧毒气体光气及其对呼气峰值流速的影响。
Chronic Low-dose Exposure to Highly Toxic Gas Phosgene and Its Effect on Peak Expiratory Flow Rate.
作者信息
Tiwari Rajnarayan R, Raghavan Sampathraju
机构信息
Department of Environmental Epidemiology, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India.
Department of Industrial Hygiene, CMR- Regional Occupational Health Centre (Southern), Bengaluru, Karnataka, India.
出版信息
Indian J Occup Environ Med. 2022 Jul-Sep;26(3):189-192. doi: 10.4103/ijoem.ijoem_417_20. Epub 2022 Sep 26.
INTRODUCTION
Phosgene is a highly toxic gas causing irritation of the airways and eyes though at high dose exposure. The effect on airways can be assessed by peak expiratory flow rate (PEFR) which is a cheaper, simple, and easy to perform test under field conditions and routine monitoring. Thus, this study is undertaken to understand the effect of chronic low-dose phosgene exposure on PEFR and the associated factors.
METHODS
This study included 287 workers of phosgene production and captive units. After recording the demographic, occupational, and clinical history on a questionnaire, every participant was subjected to clinical examination, chest radiography, and measurement of PEFR using Spirovit SP-10.
RESULTS
The mean age and mean duration of the job of participants was 42.8 ± 10.4 years and 18.9 ± 9.6 years, respectively. The PEFR was significantly reduced with increasing age, increasing duration in the job, and those having direct exposure.
CONCLUSION
PEFR is affected by chronic low-dose exposure to phosgene.
引言
光气是一种剧毒气体，高剂量接触时会刺激呼吸道和眼睛。气道影响可通过呼气峰值流速（PEFR）评估，该测试成本较低、操作简单，且易于在现场条件和常规监测下进行。因此，开展本研究以了解慢性低剂量光气暴露对PEFR及相关因素的影响。
方法
本研究纳入了287名光气生产及自备装置的工人。通过问卷记录人口统计学、职业和临床病史后，对每位参与者进行临床检查、胸部X光检查，并使用Spirovit SP-10测量PEFR。
结果
参与者的平均年龄和平均工作年限分别为42.8±10.4岁和18.9±9.6年。随着年龄增长、工作年限增加以及直接接触者，PEFR显著降低。
结论
慢性低剂量光气暴露会影响PEFR。
Zotero 插件