Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Department of Data & Analytics, WuXi Diagnostics Innovation Research Institute, Shanghai，200131, People's Republic of China.
Pharmacogenomics. 2022 Dec;23(18):961-972. doi: 10.2217/pgs-2022-0123. Epub 2022 Nov 21.
To investigate the influence of and polymorphisms on tarcolimus metabolism and renal function for renal transplantation recipients at a stable period. and polymorphisms, together with other clinical factors, were collected for 149 renal transplantation patients at postoperative stable period. Statistics analysis was performed to explore key factors affecting tarcolimus metabolism. and significantly impacted tacrolimus metabolism (p < 0.001). allele and allele were associated with poorer tacrolimus metabolic capability. Patients with various tacrolimus metabolism rates presented little difference in renal functions at stable period. Genotyping of and might benefit the precision dosage of tacrolimus for renal transplantation recipients.
为了研究 和 多态性对处于稳定期的肾移植受者他克莫司代谢和肾功能的影响。
收集了 149 例术后稳定期肾移植患者的 和 多态性及其他临床因素。对影响他克莫司代谢的关键因素进行统计学分析。 和 多态性显著影响他克莫司的代谢（p<0.001）。 等位基因和 等位基因与较差的他克莫司代谢能力相关。在稳定期，具有不同他克莫司代谢率的患者其肾功能差异不大。 和 基因分型可能有助于肾移植受者他克莫司的精准剂量。
