Influence of , polymorphisms and metabolism rate on tacrolimus exposure in renal post-transplant recipients.

To investigate the influence of and polymorphisms on tarcolimus metabolism and renal function for renal transplantation recipients at a stable period. and polymorphisms, together with other clinical factors, were collected for 149 renal transplantation patients at postoperative stable period. Statistics analysis was performed to explore key factors affecting tarcolimus metabolism. and significantly impacted tacrolimus metabolism (p < 0.001). allele and allele were associated with poorer tacrolimus metabolic capability. Patients with various tacrolimus metabolism rates presented little difference in renal functions at stable period. Genotyping of and  might benefit the precision dosage of tacrolimus for renal transplantation recipients.