Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
J Magn Reson Imaging. 2023 Aug;58(2):510-517. doi: 10.1002/jmri.28534. Epub 2022 Nov 21.
Increasing evidence has indicated that the entire visual pathway from retina to visual cortex may be involved in dysthyroid optic neuropathy (DON) pathological mechanisms.
To explore the functional and morphological brain characteristics in DON and their relationship with ophthalmologic performance.
Retrospective.
A total of 30 DON patients, 40 thyroid-associated ophthalmopathy (TAO) without DON patients and 21 healthy-controls (HCs).
FIELD STRENGTH/SEQUENCE: A 3.0 T, 3D T1-weighted spoiled gradient-recalled echo and gradient-recalled echo-planar imaging.
Functional and structural alterations in brain regions were evaluated with fractional amplitude of low-frequency fluctuations, degree centrality (DC), and gray matter volume (GMV). Clinical activity score (CAS) is assessed across patients.
One-way analysis of variance with post hoc two sample t-tests (GRF-corrected, voxel level: P < 0.005, cluster level: P < 0.05) and correlation analysis (significance level: P < 0.05).
Compared to HCs, DON patients had significantly decreased DC values in the bilateral BA17 and BA18 regions. Compared to the TAO group, DON patients had decreased GMV in the left anterior cingulate cortex, left middle frontal gyrus, left lingual gyrus, left parietal gyrus, right Rolandic operculum, left supplementary motor area, and right middle temporal gyrus. In addition, GMV in the right Rolandic operculum was significantly positively correlated with CAS (correlation coefficient: r = 0.448).
This study showed significant morphological and functional alterations in visual cortex and morphological alterations in partial default mode network regions of DON patients, which may provide insights into the mechanism of vision loss and may facilitate the diagnosis and treatment of DON.
Stage 3.
越来越多的证据表明，从视网膜到视皮层的整个视觉通路都可能参与了甲状腺相关眼病性视神经病变（DON）的病理机制。
探讨 DON 患者的脑功能和形态学特征及其与眼科表现的关系。
回顾性研究。
共纳入 30 例 DON 患者、40 例无 DON 的甲状腺相关眼病（TAO）患者和 21 例健康对照者（HCs）。
磁场强度/序列：3.0T 3D 扰相梯度回波和梯度回波平面成像。
采用低频振幅分数、度中心度（DC）和灰质体积（GMV）评估脑区的功能和结构改变。对患者进行临床活动评分（CAS）评估。
采用单因素方差分析，组间两两比较采用两样本 t 检验（GRF 校正，体素水平：P<0.005，簇水平：P<0.05）和相关性分析（显著性水平：P<0.05）。
与 HCs 相比，DON 患者双侧 BA17 和 BA18 区的 DC 值显著降低。与 TAO 组相比，DON 患者左前扣带回、左额中回、左舌回、左顶叶、右 Rolandic 盖部、左辅助运动区和右颞中回的 GMV 降低。此外，右 Rolandic 盖部 GMV 与 CAS 呈显著正相关（相关系数：r=0.448）。
本研究显示 DON 患者视皮层存在明显的形态和功能改变，部分默认模式网络区域存在形态改变，这可能为视力丧失的机制提供了新的见解，并有助于 DON 的诊断和治疗。
3 级。
3 级。
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