Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.
CNS Neurosci Ther. 2024 Jul;30(7):e14820. doi: 10.1111/cns.14820.
To investigate the alterations of the optic nerve and visual cortex in dysthyroid optic neuropathy (DON), a subgroup of thyroid eye disease (TED).
Multiple orbital imaging biomarkers related to optic nerve compression and the amplitude of low-frequency fluctuations (ALFF) of the brain were obtained from 47 patients with DON, 56 TED patients without DON (nDON), and 37 healthy controls (HC). Correlation analyses and diagnostic tests were implemented.
Compared with HC, the nDON group showed alterations in orbital imaging biomarkers related to optic nerve compression in posterior segments, as well as ALFF of the right inferior temporal gyrus and left fusiform gyrus. DON differed from nDON group mainly in the modified muscle index of the posterior segment of optic nerve, and ALFF of orbital part of right superior frontal gyrus, right hippocampus, and right superior temporal gyrus. Orbital and brain imaging biomarkers were significantly correlated with each other. Diagnostic models attained an area under a curve of 0.80 for the detection of DON.
The combined orbital and brain imaging study revealed alterations of the visual pathway in patients with TED and DON as well as provided diagnostic value. The initiation of alterations in the visual cortex in TED may precede the onset of DON.
研究甲状腺相关眼病（TED）亚组——甲状腺机能亢进性眼病（DON）中视神经和视皮层的改变。
从 47 例 DON 患者、56 例无 DON 的 TED 患者（nDON）和 37 例健康对照（HC）中获得与视神经受压相关的多个眼眶成像生物标志物和大脑低频波动幅度（ALFF）。进行了相关性分析和诊断测试。
与 HC 相比，nDON 组在后段视神经受压相关的眼眶成像生物标志物以及右侧颞下回和左侧梭状回的 ALFF 均发生改变。DON 与 nDON 组的主要区别在于视神经后段改良肌指数以及眶部右侧额上回、右侧海马体和右侧颞上回的 ALFF。眼眶和脑部成像生物标志物之间存在显著相关性。诊断模型对 DON 的检测曲线下面积为 0.80。
眼眶和脑部联合成像研究显示 TED 患者的视觉通路发生了改变，并提供了诊断价值。TED 中视皮层改变的发生可能早于 DON 的发生。
