Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Department of Radiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
J Surg Oncol. 2023 Mar;127(4):625-632. doi: 10.1002/jso.27142. Epub 2022 Nov 21.
Intraductal papillary mucinous neoplasms (IPMNs) have the potential to become malignant. Few studies have focused on the prevalence of the diabetes mellitus (DM) in IPMNs and its association with malignancy. We evaluated the association between DM and malignant IPMNs in this study.
A total of 226 patients with pathologically confirmed IPMNs were included. Demographic data, serum biochemical data, and imaging findings were collected. The malignant IPMNs were defined as those with high-grade dysplasia and associated invasive carcinoma. The association between DM and malignant IPMNs was studied using logistic regression analysis.
The prevalence of DM was 17.7% for all type IPMNs and 31.7% for malignant IPMNs. Compared to patients without DM, those with DM had a 3.6-fold (odds ratio [OR]: 3.62; 95% confidence interval [CI]: 1.26-10.44) higher risk of invasive carcinoma and 2.5-fold (OR: 2.48; 95% CI: 1.06-5.77) higher risk of malignant IPMNs. Similar results were observed in main pancreatic duct (MPD) involved IPMNs. New-onset DM was associated with a 4.13-fold (OR: 4.13, 95% CI: 1.27-13.36) higher risk of invasive carcinoma.
DM is associated with a higher risk of malignant IPMNs and invasive carcinoma, especially in patients with MPD-involved IPMNs.
导管内乳头状黏液性肿瘤（IPMN）有恶变的可能。很少有研究关注 IPMN 中糖尿病（DM）的患病率及其与恶性肿瘤的关系。我们在这项研究中评估了 DM 与恶性 IPMN 之间的关系。
共纳入 226 例经病理证实的 IPMN 患者。收集了人口统计学数据、血清生化数据和影像学结果。恶性 IPMN 定义为高级别异型增生和伴发浸润性癌。使用逻辑回归分析研究 DM 与恶性 IPMN 之间的关系。
所有 IPMN 的 DM 患病率为 17.7%，恶性 IPMN 的 DM 患病率为 31.7%。与无 DM 的患者相比，有 DM 的患者发生浸润性癌的风险增加 3.6 倍（比值比 [OR]：3.62；95%置信区间 [CI]：1.26-10.44），发生恶性 IPMN 的风险增加 2.5 倍（OR：2.48；95% CI：1.06-5.77）。在主胰管（MPD）受累的 IPMN 中也观察到了类似的结果。新发 DM 与浸润性癌的风险增加 4.13 倍（OR：4.13，95% CI：1.27-13.36）相关。
DM 与恶性 IPMN 和浸润性癌的风险增加相关，尤其是在 MPD 受累的 IPMN 患者中。
