一种水溶性噻吩-方酸菁染料，具有高摩尔消光系数，用于近红外荧光成像引导的癌症协同光热/光动力治疗。
A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer.
作者信息
Pang E, Huang Rong, Zhao Shaojing, Yang Ke, Li Baoling, Tan Qiuxia, Tan Siyi, Lan Minhuan, Wang Benhua, Song Xiangzhi
机构信息
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, P. R. China.
Huazhi medical laboratory Co., Ltd, 618 Heping Road, Changsha, 410125, P. R. China.
出版信息
J Mater Chem B. 2022 Dec 7;10(47):9848-9854. doi: 10.1039/d2tb01772e.
Phototherapeutic agents with near-infrared (NIR) fluorescence, strong reactive oxygen species generation and photothermal conversion capabilities are highly desirable for use in cancer therapy. Herein, a water-soluble NIR croconaine dye (TCR) with a thiophene-croconaine rigid core and two symmetric alkyl chains was designed and synthesized. TCR exhibits intense NIR absorption and fluorescence that peaked at 780 and 815 nm, respectively, with a high molar extinction coefficient of 1.19 × 10 M cm. Moreover, TCR has a high photothermal conversion efficiency of 77% and is capable of generating hydroxyl radicals (OH˙) under 735 nm laser irradiation. Based on these outstanding properties, TCR has proven its application in NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer.
具有近红外（NIR）荧光、强活性氧生成能力和光热转换能力的光治疗剂在癌症治疗中具有很高的应用价值。在此，设计并合成了一种具有噻吩-藏红宁刚性核和两条对称烷基链的水溶性近红外藏红宁染料（TCR）。TCR表现出强烈的近红外吸收和荧光，分别在780和815nm处达到峰值，摩尔消光系数高达1.19×10 M cm。此外，TCR具有77%的高光热转换效率，并且在735nm激光照射下能够产生羟基自由基（OH˙）。基于这些优异的性能，TCR已证明其在近红外荧光成像引导的癌症光热/光动力协同治疗中的应用。
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