去甲肾上腺素联合西咪替丁治疗新生儿上消化道出血的临床疗效及其不良反应

Clinical efficacy of norepinephrine combined with cimetidine in treatment of neonatal upper gastrointestinal hemorrhage and its adverse reactions.

作者信息

Dong Xuyan, Li Hongjun, Zhu Tianjiao

机构信息

Xuyan Dong, Department of Obstetrics, Huangshi Maternity & Children's Health Hospital, Edong Healthcare Group, Women's & Children's Hospital Affiliated to Hubei Polytechnic University, Xianning 435003, Hubei, P.R. China.

Hongjun Li, Department of Obstetrics, Xiaogan xiaonan district maternal and child care service center, Xiaogan 432100, Hubei, P.R. China.

出版信息

Pak J Med Sci. 2022 Nov-Dec;38(8):2215-2219. doi: 10.12669/pjms.38.8.5732.

DOI:10.12669/pjms.38.8.5732

PMID:36415239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9676592/

Abstract

OBJECTIVES

To investigate the clinical efficacy of norepinephrine combined with cimetidine in the treatment of neonatal upper gastrointestinal hemorrhage and its adverse reactions.

METHODS

A total of 68 cases of neonatal upper gastrointestinal hemorrhage in Huangshi Maternal and Child Health Care Hospital from please mention dates October 2018 to February 2020 were selected and randomly divided into treatment group and control group by coin tossing, with 34 infants in each group. The control group received conventional therapy, and the treatment group was additionally treated with norepinephrine combined with cimetidine. The efficacy and safety were compared between the two groups.

RESULTS

The time when the bleeding stops, the time of fecal occult blood turning negative and hospital stay of the treatment group were shorter than those of the control group ( < 0.05). Superoxide dismutase (SOD) level increased while malondialdehyde (MDA) level decreased in both groups after treatment compared with those before treatment ( < 0.05). After treatment, the SOD level was higher while the MDA level was lower in the treatment group than those in the control group ( < 0.05). The effective rate of the treatment group was higher than that of the control group ( < 0.05). However, no significance was found in adverse reactions between the two groups ( > 0.05).

CONCLUSION

Norepinephrine combined with cimetidine in the treatment of neonatal upper gastrointestinal hemorrhage can shorten the recovery time of symptoms, improve efficacy and reduce stress reaction. It is safe, effective and worthy of use in clinical practice.

摘要

目的

探讨去甲肾上腺素联合西咪替丁治疗新生儿上消化道出血的临床疗效及其不良反应。

方法

选取黄石市妇幼保健院2018年10月至2020年2月期间收治的68例新生儿上消化道出血患儿，采用抛硬币法随机分为治疗组和对照组，每组34例。对照组采用常规治疗，治疗组在常规治疗基础上加用去甲肾上腺素联合西咪替丁治疗。比较两组的疗效及安全性。

结果

治疗组的止血时间、粪隐血转阴时间及住院时间均短于对照组（P<0.05）。两组治疗后超氧化物歧化酶（SOD）水平均升高，丙二醛（MDA）水平均降低，与治疗前比较差异有统计学意义（P<0.05）。治疗后，治疗组的SOD水平高于对照组，MDA水平低于对照组（P<0.05）。治疗组的有效率高于对照组（P<0.05）。然而，两组不良反应比较差异无统计学意义（P>0.05）。