The storage, synthesis, release, measurement, carriage, action and blockade of the hormones of the renin-angiotensin system are considered, with emphasis given to the effects of intrarenal vasodilatation and vasoconstriction on renin release. The concept that variation of calcium flux in the juxtaglomerular cell is the possible final step in renin release is considered. Changing views on the main site of action of angiotensin are examined, particularly in control of the cardiovascular system and of drinking behavior through a site of action in the brain. The role that blockade of various parts of the renin-angiotensin system has played in elucidating the mechanism of action of the system is discussed. The need to consider specificity of blockade in such research is emphasized. Modification of the action of angiotensin by possible initiation of a chemical cascade involving the release of other active substances is discussed. Finally, the major functions of the renin-angiotensin system in the control of blood pressure, of sodium and water balance, and of intrarenal events, are summarized.
本文探讨了肾素-血管紧张素系统激素的储存、合成、释放、测量、运输、作用及阻断，重点关注肾内血管舒张和收缩对肾素释放的影响。文中还考虑了肾小球旁细胞钙通量变化可能是肾素释放最终步骤的观点。审视了关于血管紧张素主要作用部位的不断变化的观点，特别是在通过脑内作用部位控制心血管系统和饮水行为方面。讨论了阻断肾素-血管紧张素系统各个部分在阐明该系统作用机制中所起的作用。强调了在这类研究中考虑阻断特异性的必要性。探讨了通过可能启动涉及其他活性物质释放的化学级联反应来改变血管紧张素作用的问题。最后，总结了肾素-血管紧张素系统在控制血压、钠水平衡和肾内事件方面的主要功能。
