Chiari I 畸形的临床表现。

Clinical Manifestations of Chiari I Malformation.

机构信息

Division of Neurological Surgery, Nationwide Children's Hospital, Columbus, OH, USA; Division of Neurosurgery, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada.

Division of Neurological Surgery, Nationwide Children's Hospital, Columbus, OH, USA; Department of Neurological Surgery, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Nationwide Children's Hospital, The Ohio State College of Medicine, 700 Children's Drive, Columbus, OH 43205, USA.

出版信息

Neurosurg Clin N Am. 2023 Jan;34(1):25-34. doi: 10.1016/j.nec.2022.09.003.

DOI:10.1016/j.nec.2022.09.003

PMID:36424061

Abstract

Chiari 1 malformation (CM1) includes a spectrum of clinical manifestations. These signs and symptoms result from compression at the cervicomedullary junction and alteration in cerebrospinal fluid dynamics thus affecting several structures above, at, and below the cervicomedullary junction. Differences in presentation exist among different age groups and high clinical suspicion should be present in younger children. Additionally, CM1 can be associated with other diagnoses and can have unusual acute presentations that should be recognized to ensure excellent outcomes..

摘要

Chiari 1 畸形（CM1）包括一系列临床表现。这些体征和症状是由于颈髓结合部受压和脑脊液动力学改变引起的，从而影响颈髓结合部上下的多个结构。不同年龄段的表现存在差异，在年幼的儿童中应高度怀疑存在这种情况。此外，CM1 可与其他诊断相关联，也可能会出现不寻常的急性表现，应予以识别，以确保取得良好的结果。