Zeng Feng, Zheng Jiawei, Shen Li, Herrera-Balandrano Daniela D, Huang Wuyang, Sui Zhongquan
Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, PR China; Medical College, Yangzhou University, Yangzhou 225000, PR China; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, PR China; School of Food & Bioengineering, Jiangsu University, Zhenjiang 212013, PR China.
Nutr Metab Cardiovasc Dis. 2023 Jan;33(1):38-46. doi: 10.1016/j.numecd.2022.10.011. Epub 2022 Oct 18.
Over-nourishment or an unbalanced diet has been linked to an increase in the prevalence of metabolic syndrome. An imbalance in glucolipid metabolism is a major cause of metabolic syndrome, which has consequences for human health. Toll-like receptor 4 (TLR4), a member of the innate immune pattern recognition receptor family, is involved in inflammation-related disorders, autoimmune diseases, and tumors. Recent research has shown that TLR4 plays a key role in glucolipid metabolism, which is linked to insulin resistance, intestinal flora, and the development of chronic inflammation. TLR4 activation regulates glucolipid metabolism and contributes to the dynamic relationship between innate immunity and nutrition-related disorders. Further, TLR4 regulates glucolipid metabolism by controlling glycolysis and pyruvate oxidative decarboxylation, interfering with insulin signaling, regulating adipogenic gene expression levels, influencing preadipocyte differentiation and lipid accumulation, and altering the intestinal microbiota and permeability. TLR4 functions may provide new therapeutic applications for the prevention and treatment of metabolic syndrome. The purpose of this review is to enrich mechanistic research of diabetes, atherosclerosis, and other nutrition-related disorders by summarizing the role of TLR4 in the regulation of glucolipid metabolism as well as its physiological mechanisms.
营养过剩或饮食不均衡与代谢综合征患病率的增加有关。糖脂代谢失衡是代谢综合征的主要原因，对人类健康有影响。Toll样受体4（TLR4）是先天性免疫模式识别受体家族的成员，参与炎症相关疾病、自身免疫性疾病和肿瘤。最近的研究表明，TLR4在糖脂代谢中起关键作用，这与胰岛素抵抗、肠道菌群和慢性炎症的发展有关。TLR4激活调节糖脂代谢，并有助于先天免疫与营养相关疾病之间的动态关系。此外，TLR4通过控制糖酵解和丙酮酸氧化脱羧、干扰胰岛素信号传导、调节脂肪生成基因表达水平、影响前脂肪细胞分化和脂质积累以及改变肠道微生物群和通透性来调节糖脂代谢。TLR4的功能可能为代谢综合征的预防和治疗提供新的治疗应用。本综述的目的是通过总结TLR4在糖脂代谢调节中的作用及其生理机制，丰富对糖尿病、动脉粥样硬化和其他营养相关疾病的机制研究。
