Granholm N H, Dickens G A
J Reprod Fertil. 1986 Nov;78(2):749-53. doi: 10.1530/jrf.0.0780749.
This study was conducted to determine whether reproductive failures in ageing, obese lethal yellow (Ay/a) females are due primarily to defects within Ay/a ovaries or to systemic defects which may operate outside the ovaries. Reciprocal ovary transplantation between control (a/a) and lethal yellow (Ay/a) females provided an experimental system to test the reproductive potential of not only Ay/a ovaries in control (a/a) females but also control (a/a) ovaries in mutant (Ay/a) females. Results on reproductive performance of all four combinations of grafts between Ay/a and a/a mice proved that Ay-induced reproductive failures are not due to intrinsic ovarian lesions but rather to defects operating extrinsically to the ovary. The hypothalamo-pituitary axis is a likely site for this reproductive lesion.
本研究旨在确定衰老、肥胖的致死黄色（Ay/a）雌性小鼠的生殖失败主要是由于Ay/a卵巢内的缺陷，还是由于可能在卵巢外起作用的全身性功能缺陷。在对照（a/a）和致死黄色（Ay/a）雌性小鼠之间进行的相互卵巢移植提供了一个实验系统，不仅可以测试Ay/a卵巢在对照（a/a）雌性小鼠中的生殖潜力，还可以测试对照（a/a）卵巢在突变体（Ay/a）雌性小鼠中的生殖潜力。Ay/a和a/a小鼠之间所有四种移植组合的生殖性能结果证明，Ay诱导的生殖失败不是由于卵巢内在病变，而是由于卵巢外起作用的缺陷。下丘脑-垂体轴可能是这种生殖病变的发生部位。
