慢性炎症性眼病治疗中免疫抑制治疗的患者依从性。
Patient Adherence to Immunosuppressive Therapy in Treatment of Chronic Inflammatory Eye Disease.
机构信息
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA.
出版信息
Ocul Immunol Inflamm. 2024 Jan;32(1):5-10. doi: 10.1080/09273948.2022.2145314. Epub 2022 Nov 28.
TITLE
Patient Adherence to Immunosuppressive Therapy for Chronic Inflammatory Eye Disease.
PURPOSE
To investigate adherence rates to immunosuppressive therapy (IMT) for treatment of noninfectious inflammatory eye disease (IED), adherence and disease control, and factors associated with nonadherence.
METHOD
Retrospective review of medical charts from 2015 to 2020 was conducted on patients with IED at 6 months, 1 and 2 years after initiation of IMT.
RESULTS
Of 183 patients, adherence rates at 6 months and 1 year were 70% and 58% by 2 years. Eighty-two percent, 78%, and 65% of patients with disease quiescence were adherent at 6 months, 1 and 2 years, respectively. Adherent patients have 1.86 (95% CI 1.09, 3.20) times greater likelihood for disease control compared to nonadherent. Primary reason for nonadherence was patient self-discontinuation. No specific factors were associated with nonadherence.
CONCLUSION
Patients on IMT for IED had steady adherence rates up to 1 year, with decreased adherence at 2 years. Adherence to IMT significantly correlates with disease quiescence.
标题
慢性炎症性眼病患者对免疫抑制治疗的依从性。
目的
调查非传染性炎症性眼病（IED）治疗中免疫抑制治疗（IMT）的依从率、依从性和疾病控制情况，以及与不依从相关的因素。
方法
对 2015 年至 2020 年接受 IMT 治疗的 IED 患者的病历进行回顾性分析，分别在治疗开始后 6 个月、1 年和 2 年进行评估。
结果
在 183 名患者中，6 个月和 1 年的依从率分别为 70%和 58%，2 年时为 58%。6 个月、1 年和 2 年时，疾病静止的患者中，分别有 82%、78%和 65%的患者依从治疗。与不依从的患者相比，依从治疗的患者疾病控制的可能性高 1.86 倍（95% CI 1.09，3.20）。不依从的主要原因是患者自行停药。没有特定的因素与不依从相关。
结论
接受 IED 免疫抑制治疗的患者在 1 年内依从率稳定，但在 2 年内依从率下降。IMT 的依从性与疾病静止显著相关。
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