Sugiura Shintaro, Shintani Yuki, Mori Daisuke, Higashi Sayuri L, Shibata Aya, Kitamura Yoshiaki, Kawano Shin-Ichiro, Hirosawa Koichiro M, Suzuki Kenichi G N, Ikeda Masato
Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Nanoscale. 2023 Jan 19;15(3):1024-1031. doi: 10.1039/d2nr04556g.
The artificial construction of multicomponent supramolecular materials comprising plural supramolecular architectures that are assembled orthogonally from their constituent molecules has attracted growing attention. Here, we describe the design and development of multicomponent supramolecular materials by combining peptide-based self-assembled fibrous nanostructures with globular DNA nanoflowers constructed by the rolling circle amplification reaction. The orthogonally constructed architectures were dissected by fluorescence imaging using the selective fluorescence staining procedures adapted to this study. The present, unique hybrid materials developed by taking advantage of each supramolecular architecture based on their peptide and DNA functions may offer distinct opportunities to explore their bioapplications as a soft matrix.
由多个超分子结构组成的多组分超分子材料的人工构建引起了越来越多的关注，这些超分子结构由其组成分子正交组装而成。在这里，我们描述了通过将基于肽的自组装纤维纳米结构与通过滚环扩增反应构建的球状DNA纳米花相结合来设计和开发多组分超分子材料。通过使用适用于本研究的选择性荧光染色程序，通过荧光成像剖析正交构建的结构。利用基于肽和DNA功能的每种超分子结构开发的目前独特的杂化材料，可能为探索其作为软基质的生物应用提供独特的机会。
