Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Microbiol. 2022 Nov 29;80(1):9. doi: 10.1007/s00284-022-03116-9.
Cytomegalovirus (CMV) reactivation remains a common opportunistic infection with a prominent role in immune reconstitution in organ transplant recipients. CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. Our findings describe distinct immune signatures that emerged with CMV reactivation after kidney transplantation, which may be helpful in the timely management of CMV infection in KTRs.
巨细胞病毒 (CMV) 再激活仍然是器官移植受者免疫重建中常见的机会性感染，其在其中起着重要作用。CMV 作为自然杀伤 (NK) 细胞分化的重要驱动因素，已被证明会促使这些细胞发生几种表型和功能改变。我们旨在监测 NK 细胞的重建，并在肾移植后 6 个月的 CMV 再激活关键阶段改变炎症蛋白的特征。本研究表明，CMV 再激活与 IL-6、IL-10 和细胞毒性颗粒（包括颗粒酶-B 和粒溶素）的发展以及具有再激活的肾移植受者（KTR）中 CD16+NKG2A-CD57+NK 细胞亚群频率的下降有关。我们的研究结果描述了在肾移植后 CMV 再激活时出现的独特免疫特征，这可能有助于及时管理 KTR 中的 CMV 感染。
