Jamil Sidra, Batool Saima, Ehsan Ullah Saad, Aschalew Yared N, Zahra Tafseer, Maheshwari Leladher, Anirudh Chunchu Venkata, Amin Adil
Accident and Emergency, Glan Clwyd Hospital, Rhyl, GBR.
Internal Medicine, Hameed Latif Hospital, Lahore, PAK.
Cureus. 2022 Oct 27;14(10):e30742. doi: 10.7759/cureus.30742. eCollection 2022 Oct.
Adequate periprocedural anticoagulation is important to prevent complications like transient ischemic attack, stroke, severe esophageal injury, and pulmonary vein stenosis. The aim of this meta-analysis was to compare uninterrupted anticoagulation therapy with interrupted anticoagulation therapy for patients with arrhythmias undergoing catheter ablation. The current meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Several online databases were searched, such as PubMed, Cochrane Library, and Embase, to search for relevant randomized controlled trials (RCTs). The primary outcome included thromboembolic events. Secondary outcomes included major bleeding events and minor bleeding events. A total of eight RCTs were included in the current meta-analysis, encompassing a total of 3893 patients. No significant differences were reported in relation to thromboembolic events (RR: 2.39, 95% CI: 0.41-13.97, p-value: 0.33), major bleeding events (RR: 0.99, 95% CI: 0.50-1.96, p-value: 0.98) and minor bleeding events (RR: 1.55, 95% CI: 0.56-4.30, p-value: 0.40) between the two study groups. This meta-analysis did not find any conclusive evidence for the absence of any difference between the two strategies.
围手术期进行充分的抗凝治疗对于预防诸如短暂性脑缺血发作、中风、严重食管损伤和肺静脉狭窄等并发症至关重要。本荟萃分析的目的是比较持续性抗凝治疗与间歇性抗凝治疗对接受导管消融术的心律失常患者的疗效。本荟萃分析遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南。检索了多个在线数据库，如PubMed、Cochrane图书馆和Embase，以查找相关的随机对照试验（RCT）。主要结局包括血栓栓塞事件。次要结局包括大出血事件和小出血事件。本荟萃分析共纳入了8项RCT，总计3893例患者。在血栓栓塞事件（风险比：2.39，95%置信区间：0.41 - 13.97，p值：0.33）、大出血事件（风险比：0.99，95%置信区间：0.50 - 1.96，p值：0.98）和小出血事件（风险比：1.55，95%置信区间：0.56 - 4.30，p值：0.40）方面，两个研究组之间未报告有显著差异。本荟萃分析未找到确凿证据表明这两种策略之间不存在差异。
