Havrankova J, Schmechel D, Roth J, Brownstein M
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5737-41. doi: 10.1073/pnas.75.11.5737.
Insulin concentrations in acid/ethanol extracts of the whole rat brain were on the average 25 times higher than plasma insulin levels. Brain insulin was indistinguishable from authentic pancreatic insulin, based on its behavior in radioimmunoassay, radioreceptor assay, and bioassay and its chromatographic pattern on Sephadex G-50 column chromatography. Insulin was found in all regions of the brain examined, but distribution was uneven. Some regions had insulin concentrations as much as 100 times higher than in plasma; levels at least 10 times higher were found in other regions. The role of insulin in the central nervous system is not clear at present but, because both insulin and insulin receptors are abundant in the central nervous system, an extensive physiological regulation of the central nervous system by insulin is proposed.
全大鼠脑的酸/乙醇提取物中的胰岛素浓度平均比血浆胰岛素水平高25倍。基于其在放射免疫测定、放射受体测定和生物测定中的表现以及在葡聚糖G-50柱色谱上的色谱图谱，脑胰岛素与正宗的胰腺胰岛素无法区分。在所检查的脑的所有区域均发现了胰岛素，但分布不均。一些区域的胰岛素浓度比血浆中的高100倍；在其他区域发现的水平至少比血浆高10倍。目前尚不清楚胰岛素在中枢神经系统中的作用，但是，由于胰岛素和胰岛素受体在中枢神经系统中都很丰富，因此有人提出胰岛素对中枢神经系统有广泛的生理调节作用。
