Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Department of Radiological Sciences, University of California, Irvine, CA, USA.
Medicine (Baltimore). 2022 Nov 25;101(47):e31424. doi: 10.1097/MD.0000000000031424.
Glenohumeral joint (GHJ) space narrowing has been demonstrated to be an important morphologic parameter of glenohumeral osteoarthritis (GHO). However, the morphology of GHJ space is irregular because of degeneration of subchondral bone and articular cartilage. Thus, we devised GHJ cartilage cross-sectional area (GHJCCSA) as a new diagnostic morphological parameter to assess the irregular morphologic change of GHJ. GHJ samples were acquired from 33 patients with GHO and from 33 normal controls without evidence of GHO based on shoulder magnetic resonance imaging. T2-weighted coronal MRIs were collected at the GHJ level for all individuals. GHJCCSA and GHJ cartilage thickness (GHJCT) at the GHJ were measured on MRIs using a graphic measuring system. The GHJCCSA was measured as the whole cartilage cross-sectional area of the GHJ. The average GHJCCSA was 115.28 ± 17.36 mm2 in normal individuals and 61.77 ± 13.74 mm2 in the GHO group. The mean GHJCT was 2.06 ± 0.35 mm in normal individuals and 1.50 ± 0.28 mm in the GHO group. GHO patients had significantly lower GHJCCSA (P < .001) and GHJCT (P < .001) than normal individuals. Receiver operator characteristics curve analysis revealed that the optimal cutoff score of the GHJCCSA was 82.21 mm2, with a sensitivity of 97.0%, a specificity of 97.0%, and an area under the curve of 0.99 (95% CI: 0.97-1.00). Although GHJCCSA and GHJCT were both significantly associated with GHO, the GHJCCSA was a more sensitive measurement parameter.
肩肱关节（GHJ）间隙变窄已被证明是肩肱关节炎（GHO）的重要形态学参数。然而，由于软骨下骨和关节软骨的退化，GHJ 间隙的形态不规则。因此，我们设计了 GHJ 软骨横截面积（GHJCCSA）作为评估 GHJ 不规则形态变化的新的诊断形态学参数。根据肩部磁共振成像（MRI），从 33 名 GHO 患者和 33 名无 GHO 证据的正常对照者中获得 GHJ 样本。所有个体均在 GHJ 水平采集 T2 加权冠状 MRI。使用图形测量系统在 MRI 上测量 GHJ 的 GHJCCSA 和 GHJ 软骨厚度（GHJCT）。GHJCCSA 测量为 GHJ 的整个软骨横截面积。正常个体的平均 GHJCCSA 为 115.28 ± 17.36mm2，GHO 组为 61.77 ± 13.74mm2。正常个体的平均 GHJCT 为 2.06 ± 0.35mm，GHO 组为 1.50 ± 0.28mm。GHO 患者的 GHJCCSA（P<0.001）和 GHJCT（P<0.001）明显低于正常个体。受试者工作特征曲线分析显示，GHJCCSA 的最佳截断值为 82.21mm2，其灵敏度为 97.0%，特异性为 97.0%，曲线下面积为 0.99（95%CI：0.97-1.00）。虽然 GHJCCSA 和 GHJCT 均与 GHO 显著相关，但 GHJCCSA 是一种更敏感的测量参数。
