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食管闭锁的术后并发症及内镜下球囊扩张在吻合口狭窄中的作用

Postoperative Complications of Esophageal Atresia and Role of Endoscopic Balloon Dilatation in Anastomotic Strictures.

作者信息

Cho Jin Young, Chang Mea-Young, Gang Mi Hyeon, Lee Yong Wook, Park Jun Beom, Kim Jae Young, Kim Hyun Jin

机构信息

Department of Pediatrics, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.

Division of Pediatric Surgery, Department of Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.

出版信息

Pediatr Gastroenterol Hepatol Nutr. 2022 Nov;25(6):453-460. doi: 10.5223/pghn.2022.25.6.453. Epub 2022 Nov 2.

Abstract

PURPOSE

Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is a congenital anomaly that can cause frequent digestive and nutritional problems, even after repair. The most common complication is anastomotic stricture, for which reoperation or balloon dilatation is performed. This study aimed to evaluate the postoperative complications of EA and the role of endoscopic balloon dilatation (EBD) in cases of anastomotic stricture.

METHODS

We retrospectively analyzed patients diagnosed with EA with or without TEF between January 2000 and February 2021. Patients' baseline characteristics, associated anomalies, and postoperative complications were reviewed.

RESULTS

Among 26 patients, 14 (53.8%) were male, 12 (46.2%) had coexisting anomalies, and the median follow-up was 6.1 years (range, 1.2-15.7 years). In univariate analysis, prematurity, low birth weight, and long-gap EA were associated with postoperative complications in 12 (46.2%) patients. Among the 10 (38.5%) patients with anastomotic stricture, nine (90.0%) required EBD. Regarding the first EBD, it was performed at a median of 3.3 months (range, 1.2-7.6 months) post-repair, while the average patient weight was 4.6 kg. The mean diameter ranged from 3.3 to 9.1 mm without major complications. In univariate analysis, long-gap EA alone was significantly associated with EBD.

CONCLUSION

Approximately half of the patients experienced complications after EA repair. In particular, patients with a long-gap EA had a significantly increased risk of complications, such as anastomotic strictures. EBD can be safely used, even in infants.

摘要

目的

食管闭锁(EA)伴或不伴气管食管瘘(TEF)是一种先天性异常,即使在修复后也可能导致频繁的消化和营养问题。最常见的并发症是吻合口狭窄,对此需进行再次手术或球囊扩张。本研究旨在评估EA术后并发症以及内镜球囊扩张术(EBD)在吻合口狭窄病例中的作用。

方法

我们回顾性分析了2000年1月至2021年2月期间诊断为EA伴或不伴TEF的患者。回顾了患者的基线特征、相关异常情况及术后并发症。

结果

26例患者中,14例(53.8%)为男性,12例(46.2%)存在合并异常,中位随访时间为6.1年(范围1.2 - 15.7年)。单因素分析显示,早产、低出生体重和长段EA与12例(46.2%)患者的术后并发症相关。在10例(38.5%)吻合口狭窄患者中,9例(90.0%)需要进行EBD。首次EBD在修复术后中位时间3.3个月(范围1.2 - 7.6个月)进行,此时患者平均体重为4.6 kg。平均直径范围为3.3至9.1 mm,无严重并发症。单因素分析显示,仅长段EA与EBD显著相关。

结论

约一半的患者在EA修复术后出现并发症。特别是长段EA患者发生诸如吻合口狭窄等并发症的风险显著增加。即使在婴儿中,EBD也可安全使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3d0/9679305/29257d43a78a/pghn-25-453-g001.jpg

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