Sepúlveda-Robles Omar, Jiménez-Hernández Elva, Domínguez-Catzín Victoria, Gómez-Flores Eber, Martín-Trejo Jorge Alfonso, Flores-Lujano Janet, Torres-Nava José Refugio, Núñez-Enríquez Juan Carlos, De Ita Marlon, Medina-Sanson Aurora, Mata-Rocha Minerva, Morales-Castillo Blanca Angelica, Bravata-Alcántara Juan Carlos, Nájera-Cortés Alan Steve, Sánchez-Escobar Norberto, Peñaloza-Gonzalez José Gabriel, Espinosa-Elizondo Rosa Martha, Flores-Villegas Luz Victoria, Amador-Sanchez Raquel, Orozco-Ruiz Darío, Pérez-Saldívar Maria Luisa, Velázquez-Aviña Martha Margarita, Merino-Pasaye Laura Elizabeth, Solís-Labastida Karina Anastacia, González-Ávila Ana Itamar, Santillán-Juárez Jessica Denisse, Bekker-Méndez Vilma Carolina, Jiménez-Morales Silvia, Rangel-López Angélica, Rosas-Vargas Haydeé, Mejía-Aranguré Juan Manuel
Unidad de Investigación Médica en Genética Humana, UMAE Hospital de Pediatría, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Servicio de Hematología Pediátrica, Hospital General "Gaudencio González Garza", Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Front Pediatr. 2022 Nov 14;10:946690. doi: 10.3389/fped.2022.946690. eCollection 2022.
The distribution of , , , , and in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.
We retrospectively analyzed the presence of , , , , and by RT-PCR among 77 patients (<18 years) diagnosed with AML between 2019 and 2021 in nine Mexico City hospitals.
The overall frequency of the fusion genes was 50.7%; (22.1%) and (20.8%) were the most prevalent, followed by (5.2%) and (2.4%). was not detected. Patients with showed the lowest survival with high early mortality events. However, more studies are required to evaluate the impact of analyzed fusion genes on the overall survival of the Mexican child population with AML.
The pediatric population of Mexico City with AML had frequencies of , , , and similar to those of other populations around the world. Patients with and were few or did not die, while those with was not detected. Although patients with had a low survival and a high early mortality rate, further studies are needed to determine the long-term impacts of these fusion genes on this Latino population.
拉丁美洲许多国家儿童急性髓系白血病（AML）中 、 、 、 以及 的分布情况在很大程度上尚不明确。因此，我们旨在调查墨西哥城儿童AML患者中这些融合基因的频率，墨西哥城是世界上急性白血病发病率最高的地区之一。此外，我们还探讨了它们对治疗第一年死亡率的影响。
我们回顾性分析了2019年至2021年间在墨西哥城九家医院诊断为AML的77例（<18岁）患者中通过逆转录聚合酶链反应（RT-PCR）检测到的 、 、 、 以及 的情况。
融合基因的总体频率为50.7%； （22.1%）和 （20.8%）最为常见，其次是 （5.2%）和 （2.4%）。未检测到 。 患者的生存率最低，早期死亡事件发生率高。然而，需要更多研究来评估所分析的融合基因对墨西哥儿童AML患者总体生存的影响。
墨西哥城患有AML的儿童人群中 、 、 以及 的频率与世界其他人群相似。 以及 患者很少或未死亡，而未检测到 患者。尽管 患者生存率低且早期死亡率高，但需要进一步研究来确定这些融合基因对该拉丁裔人群的长期影响。
