Wang Ye, Li Qian, Wang Song, Wang Bi-Jun, Jin Yan, Hu Hao, Fu Qing-Sheng, Wang Jia-Wei, Wu Qing, Qian Long, Cao Ting-Ting, Xia Ya-Bin, Huang Xiao-Xu, Xu Li
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wuhu, Anhui, China.
Front Oncol. 2022 Nov 14;12:1026257. doi: 10.3389/fonc.2022.1026257. eCollection 2022.
Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and migration. Specifically, recent studies have shown that ncRNAs contribute to tumorigenesis and tumor development by mediating changes in enzymes related to lipid metabolism. The purpose of this review is to discuss the characterized ncRNAs involved in the lipid metabolism of tumors to highlight ncRNA-mediated lipid metabolism-related enzyme expression in malignant tumors and its importance to tumor development. In this review, we describe the types of ncRNA and the mechanism of tumor lipid metabolism and analyze the important role of ncRNA in tumor lipid metabolism and its future prospects from the perspectives of ncRNA biological function and lipid metabolic enzyme classification. However, several critical issues still need to be resolved. Because ncRNAs can affect tumor processes by regulating lipid metabolism enzymes, in the future, we can study the unique role of ncRNAs from four aspects: disease prevention, detection, diagnosis, and treatment. Therefore, in the future, the development of ncRNA-targeted therapy will become a hot direction and shoulder a major task in the medical field.
对非编码核糖核酸（ncRNAs）的研究主要广泛聚焦于微小RNA（miRNAs）、环状RNA（circRNAs）和长链非编码RNA（lncRNAs），它们已被证实在肿瘤细胞增殖、侵袭和迁移中发挥重要作用。具体而言，近期研究表明，ncRNAs通过介导与脂质代谢相关酶的变化促进肿瘤发生和发展。本综述的目的是讨论参与肿瘤脂质代谢的特征性ncRNAs，以突出ncRNA介导的恶性肿瘤中脂质代谢相关酶表达及其对肿瘤发展的重要性。在本综述中，我们描述了ncRNA的类型和肿瘤脂质代谢机制，并从ncRNA生物学功能和脂质代谢酶分类的角度分析了ncRNA在肿瘤脂质代谢中的重要作用及其未来前景。然而，仍有几个关键问题需要解决。由于ncRNAs可通过调节脂质代谢酶影响肿瘤进程，未来，我们可以从疾病预防、检测、诊断和治疗四个方面研究ncRNAs的独特作用。因此，未来靶向ncRNA的治疗发展将成为一个热门方向，并在医学领域承担重大任务。
