Harugop Anil S, Havaldar Rajesh R, Patil P H
Department of ENT and Head and Neck Surgery, J.N. Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):821-825. doi: 10.1007/s12070-020-01872-3. Epub 2020 May 6.
To compare the effectiveness between topical mometasone furoate nasal spray versus topical fluticasone furoate nasal spray in the treatment of chronic rhinosinusitis. Randomized control trial was conducted involving 70 patients. One group received topical mometasone furoate nasal spray and the other group received fluticasone furoate nasal spray for 3 weeks. All patients were prescribed oral ciprofloxacin for 3 weeks and were subjectively evaluated using the Lund and Mackay staging system and objectively using nasal endoscopy by the Lund and Kennedy scoring system. There was no inter group significance but all patients improved significantly after the administration of either of the steroid sprays. Following administration of steroid nasal sprays, there was clinically significant improvement in the symptoms and signs of chronic rhinosinusitis, but there was no statistical significance between the two study groups. Thus, steroid nasal sprays significantly improve the symptoms and resolution of signs of chronic rhinosinusitis. The choice of drug still remains uncertain to the clinician. However, long term studies with more sample size is needed to arrive at sound conclusions.
比较糠酸莫米松鼻喷雾剂与糠酸氟替卡松鼻喷雾剂治疗慢性鼻-鼻窦炎的疗效。进行了一项随机对照试验，纳入70例患者。一组接受糠酸莫米松鼻喷雾剂治疗，另一组接受糠酸氟替卡松鼻喷雾剂治疗，为期3周。所有患者均口服环丙沙星3周，并采用Lund和Mackay分期系统进行主观评估，以及采用Lund和Kennedy评分系统通过鼻内镜进行客观评估。组间无显著差异，但使用任何一种类固醇喷雾剂后所有患者均有显著改善。使用类固醇鼻喷雾剂后，慢性鼻-鼻窦炎的症状和体征有临床显著改善，但两个研究组之间无统计学差异。因此，类固醇鼻喷雾剂可显著改善慢性鼻-鼻窦炎的症状和体征消退情况。临床医生对药物的选择仍不确定。然而，需要进行更多样本量的长期研究才能得出可靠结论。
