Division of Epidemiology, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Division of Biostatistics & Bioinformatics, Department of Environmental & Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Epigenomics. 2022 Nov;14(21):1343-1354. doi: 10.2217/epi-2022-0279. Epub 2022 Dec 1.
The objective was to identify stable and dynamic DNA methylation loci associated with cardiometabolic traits among an adult population from the Croatian island of Hvar. An epigenome-wide association study was conducted using peripheral blood longitudinally collected at two time points 10 years apart via Infinium MethylationEPIC beadarray (n = 112). Stable and dynamic loci were identified using linear mixed models. Associations between cardiometabolic traits and loci were assessed using linear models. 22 CpG loci were significantly associated with systolic blood pressure. Twenty were stable and two were dynamic. Multiple genes may be involved in the determination of systolic blood pressure level via stable epigenetic programming, potentially established earlier in life.
目的是鉴定与克羅地亞赫瓦爾島成人人群中心血管代谢特征相关的稳定和动态 DNA 甲基化基因座。采用外周血进行全基因组关联研究，这些外周血样本在相隔 10 年的两个时间点通过 Infinium MethylationEPIC 珠阵列（n=112）纵向收集。使用线性混合模型鉴定稳定和动态基因座。使用线性模型评估与心血管代谢特征相关的基因座。22 个 CpG 基因座与收缩压显著相关。其中 20 个是稳定的，2 个是动态的。通过稳定的表观遗传编程，可能在生命早期就确定了多个基因可能参与收缩压水平的决定。
