Department of Cornea and Anterior Segment Services, CL Gupta Eye Institute, Moradabad, Uttar Pradesh; The Bodhya Eye Consortium: a. Dr Shroff's Charity Eye Hospital, New Delhi, India. b. Sadguru Netra Chikitsalaya, Jankikund, Chitrakoot, Madhya Pradesh, India. c. Regional Institute of Ophthalmology and Sitapur Eye Hospital, Sitapur, Uttar Pradesh, India. d. MGM Eye Institute, Raipur, Chhattisgarh, India. e. CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India. f. LJ Eye Institute, Ambala City, Haryana, India.
Department of Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh; The Bodhya Eye Consortium: a. Dr Shroff's Charity Eye Hospital, New Delhi, India. b. Sadguru Netra Chikitsalaya, Jankikund, Chitrakoot, Madhya Pradesh, India. c. Regional Institute of Ophthalmology and Sitapur Eye Hospital, Sitapur, Uttar Pradesh, India. d. MGM Eye Institute, Raipur, Chhattisgarh, India. e. CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India. f. LJ Eye Institute, Ambala City, Haryana, India.
Indian J Ophthalmol. 2022 Dec;70(12):4263-4269. doi: 10.4103/ijo.IJO_1438_22.
This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics.
The microbiology laboratory records of 228 patients with culture-proven bacterial keratitis from 1 January to 31 December 2019 were analyzed. Cultured bacterial isolates were subjected to antimicrobial susceptibility testing to antibiotics commonly used in the treatment of corneal ulcer. Chi-squared or Fisher's exact test were applied to check the significance of difference between the susceptibility levels of antibiotics.
The prevalence of Staphylococcus aureus and Pseudomonas aeruginosa-induced keratitis was higher in northern India, whereas that by Streptococcus pneumoniae was more prevalent in central India. In central India, 100% of S. pneumoniae isolates were found to be sensitive to ceftriaxone compared to 79% in northern India (P = 0.017). In comparison to 67% of isolates from north India, 15% of S. aureus isolates from central India were found to be sensitive to ofloxacin (P = 0.009). Similarly, 23% of isolates from central India were found sensitive to amikacin compared to 65% of isolates from north India (P = 0.012). P. aeruginosa isolates from central India were found to be sensitive to ceftazidime in 63% of cases compared to 21% of isolates from north India (P = 0.034).
Prevalence of bacteria and their susceptibility to antibiotics are not uniform across geography. Vancomycin remained the most effective drug in all gram-positive coccal infections. S. aureus susceptibility to amikacin was significantly greater in north India. P. aeruginosa showed less susceptibility as compared to previous reports.
本研究旨在检查印度北部和中部细菌性角膜炎患者的微生物谱及其抗生素敏感性，以确保抗生素的合理使用。
分析了 2019 年 1 月 1 日至 12 月 31 日期间 228 例培养证实的细菌性角膜炎患者的微生物学实验室记录。对培养的细菌分离株进行了抗生素药敏试验，以检测常用于治疗角膜溃疡的抗生素。应用卡方检验或 Fisher 精确检验来检查抗生素敏感性水平之间差异的显著性。
在印度北部，金黄色葡萄球菌和铜绿假单胞菌引起的角膜炎更为常见，而在印度中部，肺炎链球菌引起的角膜炎更为常见。在印度中部，100%的肺炎链球菌分离株对头孢曲松敏感，而在印度北部为 79%（P=0.017）。与印度北部 67%的分离株相比，印度中部 15%的金黄色葡萄球菌分离株对氧氟沙星敏感（P=0.009）。同样，印度中部 23%的分离株对阿米卡星敏感，而印度北部为 65%（P=0.012）。与印度北部 21%的分离株相比，印度中部 63%的铜绿假单胞菌分离株对头孢他啶敏感（P=0.034）。
细菌的流行情况及其对抗生素的敏感性在地理位置上并不统一。万古霉素在所有革兰阳性球菌感染中仍然是最有效的药物。金黄色葡萄球菌对阿米卡星的敏感性在印度北部明显更高。与之前的报道相比，铜绿假单胞菌的敏感性较低。
