羊膜移植在史蒂文斯-约翰逊综合征急性眼部表现治疗中的作用及其长期影响。
Role of amniotic membrane transplantation in treating acute ocular manifestations in Steven-Johnson syndrome and its long-term impact.
机构信息
Department of Cornea and Anterior Segment, All India Institute of Medical Sciences, Patna, Bihar, India.
Department of Ophthalmology, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
出版信息
Indian J Ophthalmol. 2022 Dec;70(12):4470-4471. doi: 10.4103/ijo.IJO_1451_22.
BACKGROUND
Steven-Johnson syndrome (SJS) is a serious disorder affecting the skin and mucous membrane, causing multiple flaccid bullae and purpuric rashes with sheet-like epithelial detachment including the ocular surface. The long-term outcomes following SJS are dismal and manifest as corneal vascularization, lid-wiper keratopathy, and severe dry eyes. The disease course can be modified if amniotic membrane graft is performed at the first week of disease, and the above-said complications can be avoided. This procedure thus not only decreases the morbidity but also improves the quality of life.
PURPOSE
This video discusses the long-term sequelae of SJS which can be modified with timely intervention during the acute stage and thus significantly decreases morbidity.
SYNOPSIS
The video demonstrates the simple technique of amniotic membrane transplantation in the acute stage in SJS and its impact in long run.
HIGHLIGHTS
There should be a low threshold for doing early amniotic membrane transplantation in patients with SJS with ocular surface involvement. Early intervention can change the disease course and decrease disease morbidity significantly.
VIDEO LINK
背景
史蒂文斯-约翰逊综合征（SJS）是一种严重的皮肤和黏膜疾病，会导致多处松弛性大疱和紫癜性皮疹，伴有片状上皮脱落，包括眼表面。SJS 后的长期后果很严重，表现为角膜血管化、睑缘刷状角膜炎和严重的干眼症。如果在疾病的第一周进行羊膜移植，可以改变疾病过程，避免上述并发症。因此，该手术不仅降低了发病率，还提高了生活质量。
目的
本视频讨论了 SJS 的长期后遗症，如果在急性阶段及时干预，可以进行修正，从而显著降低发病率。
概要
该视频演示了 SJS 急性阶段羊膜移植的简单技术及其长期影响。
重点
对于有眼表面受累的 SJS 患者，应该低门槛地进行早期羊膜移植。早期干预可以改变疾病过程，显著降低疾病发病率。
Zotero 插件