Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
Department of Behavioral Science, University of Kentucky, Lexington, KY, USA.
Subst Use Misuse. 2023;58(1):66-76. doi: 10.1080/10826084.2022.2148478. Epub 2022 Dec 1.
: Cannabis is the most used federally illicit substance. Due to widespread medicinal use and state-level legalization, public perceptions of cannabis have shifted toward the assumption that cannabis is safe. However, cannabinoids can cause adverse medical complications that may lead people to seek treatment. This study characterized cannabinoid poisoning-related medical encounters, poisoning involving cannabinoids and other psychoactive substances, and cannabinoid poisoning-related cardiac complications. : Administrative billing data for emergency department visits and inpatient hospitalizations in acute care facilities with a discharge date from January 1, 2017 to December 31, 2019 were used to characterize cannabinoid poisoning events in Kentucky, identified by ICD-10-CM diagnosis code T40.7X. There were 1,490 encounters of cannabinoid poisoning; patients were primarily non-Hispanic White males, ages 15-44, who had Medicaid and lived in a metropolitan area. Of those, 31.21% involved poisoning with a second psychoactive substance, primarily stimulants and/or opioids, and 17.72% experienced a cardiac complication. Cannabinoid-polydrug poisoning was associated with inpatient treatment (χ=199.18, < 0.001) and cardiac complications (χ=4.58, < 0.001). : These results are consistent with other state-level data. Patients who were diagnosed with cannabis-polydrug poisoning, compared to cannabis alone poisoning, had greater odds of hospital admission and cardiac complications, and longer length of hospital stays. The health risks of cannabinoid use must be more broadly recognized, while timely and accurate data need to be shared to guide policies on cannabis access. Future research on cannabinoid poisoning should consider the involvement of other psychoactive drugs.
大麻是使用最广泛的联邦违禁物质。由于广泛的药用和州级合法化，公众对大麻的看法已经转向假设大麻是安全的。然而，大麻素会引起不良的医疗并发症，可能导致人们寻求治疗。本研究描述了与大麻素中毒相关的医疗接触、涉及大麻素和其他精神活性物质的中毒以及与大麻素中毒相关的心脏并发症。
使用 2017 年 1 月 1 日至 2019 年 12 月 31 日期间急性护理设施急诊就诊和住院患者的行政计费数据，通过 ICD-10-CM 诊断代码 T40.7X 确定肯塔基州的大麻素中毒事件。共有 1490 例大麻素中毒事件；患者主要是非西班牙裔白人男性，年龄在 15-44 岁之间，拥有医疗补助并居住在大都市区。其中，31.21%涉及与第二种精神活性物质（主要是兴奋剂和/或阿片类药物）中毒，17.72%出现心脏并发症。大麻素-多药中毒与住院治疗（χ=199.18，<0.001）和心脏并发症（χ=4.58，<0.001）相关。
这些结果与其他州级数据一致。与单独大麻素中毒相比，诊断为大麻素-多药中毒的患者更有可能住院和出现心脏并发症，并且住院时间更长。大麻素使用的健康风险必须得到更广泛的认识，同时需要及时准确地共享数据，以指导大麻素获取政策。未来关于大麻素中毒的研究应考虑其他精神活性药物的参与。
