Guihang Guiyang Hospital, Guiyang 550000, Guizhou Province, China.
The Fourth People's Hospital of Guiyang, Guiyang 550000, Guizhou Province, China.
Ecotoxicol Environ Saf. 2022 Dec 15;248:114346. doi: 10.1016/j.ecoenv.2022.114346. Epub 2022 Nov 28.
As BFRs have gradually been banned recently, organophosphorus flame retardants (OPFRs) have been manufactured and used in their place. Although OPFRs are considered the better alternatives to BFRs, many studies have discovered that OPFRs may be associated with various cancers, including prostate cancer, bladder cancer, hepatocellular carcinoma, and colorectal cancer. However, few studies have examined the relationship between OPFRs and gliomas. This study investigated the relationship between triphenyl phosphate (TPP) and glioma using bioinformatics analysis approaches. The comparative toxicogenomics database (CTD) and The Cancer Genome Atlas (TCGA) databases were accessed for TPP-related genes and gene expression data from glioma patients. The Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses show that TPP might be closely related to many pathways. Further, the analysis of protein-protein interactions revealed strong intrinsic relationships between TPP-related genes. In addition, the TPP-based prognostic prediction model demonstrated promising results in predicting the prognosis of patients with gliomas. Several TPP-related genes were closely related to glioma patients' overall survival rates. The proliferation and migration abilities of glioma cells were further demonstrated to be significantly enhanced by TPP. In a bioinformatics analysis, we also discovered that melatonin is highly correlated with the presence of TPP and gliomas. According to the cell proliferation and migration assays, exposure to melatonin and TPP inhibited the ability of glioma cells to invade compared with the TPP group.
随着 BFRs 最近逐渐被禁止，有机磷阻燃剂（OPFRs）已被制造并用于替代它们。虽然 OPFRs 被认为是 BFRs 的更好替代品，但许多研究发现 OPFRs 可能与各种癌症有关，包括前列腺癌、膀胱癌、肝细胞癌和结直肠癌。然而，很少有研究探讨 OPFRs 与神经胶质瘤之间的关系。本研究使用生物信息学分析方法探讨了磷酸三苯酯（TPP）与神经胶质瘤之间的关系。通过比较毒理学基因组学数据库（CTD）和癌症基因组图谱（TCGA）数据库，获得与 TPP 相关的基因和神经胶质瘤患者的基因表达数据。基因本体论（GO）富集和京都基因与基因组百科全书（KEGG）富集分析表明，TPP 可能与许多途径密切相关。此外，蛋白质-蛋白质相互作用的分析揭示了 TPP 相关基因之间的强内在关系。此外，基于 TPP 的预后预测模型在预测神经胶质瘤患者的预后方面显示出有希望的结果。一些 TPP 相关基因与神经胶质瘤患者的总生存率密切相关。进一步证实，TPP 显著增强了神经胶质瘤细胞的增殖和迁移能力。在生物信息学分析中，我们还发现褪黑素与 TPP 和神经胶质瘤的存在高度相关。根据细胞增殖和迁移实验，与 TPP 组相比，暴露于褪黑素和 TPP 可抑制神经胶质瘤细胞的侵袭能力。
