Alalaiwe Ahmed, Lin Yu-Chih, Lin Chwan-Fwu, Huang Chih-Chi, Wang Pei-Wen, Fang Jia-You
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
Eur J Pharm Sci. 2023 Jan 1;180:106344. doi: 10.1016/j.ejps.2022.106344. Epub 2022 Nov 29.
The purpose of the current investigation was to develop multifunctional TiO-embedded mesoporous silica incorporating avobenzone to protect against environmental stress through pollutant adsorption and UVA protection. We sought to explore the effect of the mesoporous porosity on the capability of contaminant capture and the suppression of avobenzone skin penetration. The porosity of the mesoporous silica was tuned by adjusting the ratio of template triblock copolymers (Pluronic P123 and F68). The Pluronic P123:F68 ratios of 3:1, 2:2, and 1:3 produced mesoporous silica with pore volumes of 0.66 (TiO/SBA-L), 0.47 (TiO/SBA-M), and 0.25 (TiO/SBA-S) cm/g, respectively. X-ray scattering and electron microscopy confirmed the SBA-15 structure of the as-prepared material had a size of 3-5 μm. The maximum adsorbability of fluoranthene and methylene blue was found to be 43% and 53% for the TiO/SBA-S under UVA light, respectively. The avobenzone loaded into the mesoporous silica demonstrated the synergistic effect of in vitro UVA protection, reaching an UVA/UVB absorbance ratio of near 1.5 (Boots star rating = 5). The encapsulation of avobenzone into the TiO/SBA-S lessened cutaneous avobenzone absorption from 0.76 to 0.50 nmol/mg, whereas no reduction was detected for the TiO/SBA-L. The avobenzone-loaded TiO/SBA-S hydrogel exhibited a greater improvement in skin barrier recovery and proinflammatory mediator mitigation compared to the SBA-S hydrogel (without TiO). The cytokines/chemokines in the photoaged skin were reduced by two- to three-fold after TiO/SBA-S treatment compared to the non-treatment control. Our data suggested that the mesoporous formulation with low porosity and a specific surface area showed effective adsorbability and UVA protection, with reduced UVA filter absorption. The versatility of the developed mesoporous system indicated a promising potential for outdoor skin protection.
当前研究的目的是开发一种多功能的、嵌入二氧化钛的介孔二氧化硅，并结合阿伏苯宗，通过污染物吸附和紫外线A防护来抵御环境压力。我们试图探究介孔孔隙率对污染物捕获能力以及对阿伏苯宗皮肤渗透抑制作用的影响。通过调整模板三嵌段共聚物（普朗尼克P123和F68）的比例来调节介孔二氧化硅的孔隙率。普朗尼克P123与F68的比例为3:1、2:2和1:3时，分别制备出孔体积为0.66（TiO/SBA-L）、0.47（TiO/SBA-M）和0.25（TiO/SBA-S）cm/g的介孔二氧化硅。X射线散射和电子显微镜证实，所制备材料的SBA-15结构尺寸为3 - 5μm。在紫外线A照射下，TiO/SBA-S对荧蒽和亚甲基蓝的最大吸附率分别为43%和53%。负载于介孔二氧化硅中的阿伏苯宗在体外展现出紫外线A防护的协同效应，紫外线A/紫外线B吸光度比接近1.5（博姿星级评定 = 5）。将阿伏苯宗包封于TiO/SBA-S中，可使皮肤对阿伏苯宗的吸收从0.76降至0.50 nmol/mg，而TiO/SBA-L未检测到吸收降低。与SBA-S水凝胶（不含TiO）相比，负载阿伏苯宗的TiO/SBA-S水凝胶在皮肤屏障恢复和促炎介质缓解方面有更大改善。与未处理的对照相比，经TiO/SBA-S处理后，光老化皮肤中的细胞因子/趋化因子减少了两到三倍。我们的数据表明，具有低孔隙率和特定表面积的介孔制剂显示出有效的吸附性和紫外线A防护能力，同时降低了紫外线过滤剂的吸收。所开发介孔系统的多功能性表明其在户外皮肤防护方面具有广阔的应用前景。
