Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
Sci Rep. 2022 Dec 1;12(1):20728. doi: 10.1038/s41598-022-24110-y.
Enteral feeding is challenging in preterm infants because of gastrointestinal (GI) immaturity. Electrogastrography (EGG) is a non-invasive technology that measures gastric myoelectrical activity and can be utilized to measure changes that occur with maturation at different gestational ages (GA). Three gastric rhythms (GR) exist between 0.5-9 cycles per minute (cpm), namely, bradygastria (0.5 ≤ GR < 2 cpm), normogastria (2 ≤ GR < 4 cpm), and tachygastria (4 ≤ GR < 9 cpm). We aimed to characterize EGG-derived parameters for different GA by quantifying (1) power spectral density (PSD) and its spectral means at three GR bands (i.e., mPSD) and (2) the percent (%) time spent in each band. Data analyzed was from a longitudinal cohort of preterm infants (n = 51) born at early, mid, and term GA of < 29, 29-33, and ≥ 37 weeks, respectively. Weekly EGG monitoring was performed until 40 weeks' postmenstrual age or discharge. Pre-, during, and post-feed data were analyzed for mPSD at each GR band. Also, % bradygastria, % normogastria, and % tachygastria were calculated by continuous wavelet transform analysis. Results showed (1) mPSD values in normogastria and tachygastria during feeding increased with advancing GA, and (2) % normogastria increased with advancing GA regardless of GR ranges, suggesting EGG may measure GI maturity in preterm infants.
肠内喂养对早产儿来说具有挑战性，因为其胃肠道（GI）不成熟。胃电图（EGG）是一种非侵入性技术，可测量胃肌电活动，并可用于测量不同胎龄（GA）成熟过程中发生的变化。存在三种胃节律（GR），频率在 0.5-9 个周期/分钟（cpm）之间，即慢波胃活动（0.5≤GR<2 cpm）、正常胃活动（2≤GR<4 cpm）和快波胃活动（4≤GR<9 cpm）。我们旨在通过量化（1）功率谱密度（PSD）及其在三个 GR 带中的谱均值（即 mPSD）和（2）每个带中花费的时间百分比（%），来描述不同 GA 的 EGG 衍生参数。分析的数据来自一个早产儿的纵向队列（n=51），分别出生于早期、中期和晚期 GA，GA<29、29-33 和≥37 周。每周进行 EGG 监测，直到出生后 40 周或出院。在每个 GR 带中，对 Pre、During 和 Post-Feed 数据进行 mPSD 分析。还通过连续小波变换分析计算了慢波胃活动的%、正常胃活动的%和快波胃活动的%。结果表明：（1）喂养期间，正常胃活动和快波胃活动的 mPSD 值随着 GA 的增加而增加；（2）无论 GR 范围如何，%正常胃活动随着 GA 的增加而增加，这表明 EGG 可能可以测量早产儿的 GI 成熟度。
