Oura Petteri, Sajantila Antti
Department of Forensic Medicine, University of Helsinki, Helsinki, Finland.
Forensic Medicine Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
J Public Health Res. 2022 Nov 24;11(4):22799036221139935. doi: 10.1177/22799036221139935. eCollection 2022 Oct.
Inpatients have a particular risk of sustaining medical adverse events (MAEs). This analysis aimed to identify patterns of change in deaths due to MAEs among US inpatients. The analysis was based on nationwide cause-of-death data from 1999 to 2019. To adjust for secular trends in overall mortality, MAE deaths were examined proportional to total deaths. Statistical analysis was performed by means of joinpoint regression modeling. Over the analysis period, a total of 18,126,135 certified deaths occurred among inpatients. MAEs were used as the underlying cause of death in 43,899 cases (0.24%). MAE deaths showed a significant increase from mid-2010s onwards; the estimated increase in MAE deaths was up to 15.6% per year (95% confidence interval 11.3-20.1) from 2014 to 2019. Procedure-related events mainly drove the trend. As the present data are insufficient to substantiate and disentangle underlying factors, future analyses are warranted.
住院患者有发生医疗不良事件（MAE）的特殊风险。本分析旨在确定美国住院患者中因MAE导致的死亡变化模式。该分析基于1999年至2019年的全国死因数据。为了调整总体死亡率的长期趋势，对MAE死亡按总死亡人数的比例进行了检查。通过连接点回归模型进行统计分析。在分析期间，住院患者中共有18126135例经认证的死亡。MAE被用作43899例（0.24%）死亡的根本原因。从2010年代中期开始，MAE死亡人数显著增加；2014年至2019年，MAE死亡人数的估计年增长率高达15.6%（95%置信区间11.3 - 20.1）。与手术相关的事件是主要驱动因素。由于目前的数据不足以证实和理清潜在因素，有必要进行未来的分析。
