Department of Pediatric Oncology and Hematology, Charité-Universitäts-medizin Berlin, Berlin, Germany.
Experimental and Clinical Research Center (ECRC) of the Charité-Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
Cancer Discov. 2022 Dec 2;12(12):2727-2729. doi: 10.1158/2159-8290.CD-22-1023.
Single biopsies fail to reflect intratumor heterogeneity and tumor evolution. In this issue of Cancer Discovery, Bosse and colleagues show an important role for circulating cell-free tumor DNA sequencing to detect the genomic evolution of neuroblastoma under ALK inhibitor therapy and identify novel (sub)clonal pathogenic variants involved in disease progression under conventional therapy. See related article by Bosse et al., p. 2800 (5).
单份活检无法反映肿瘤内异质性和肿瘤演变。在本期《癌症发现》中，Bosse 及其同事表明，循环无细胞肿瘤 DNA 测序在检测 ALK 抑制剂治疗下神经母细胞瘤的基因组演变以及鉴定在常规治疗下涉及疾病进展的新（亚）克隆致病性变异方面具有重要作用。见 Bosse 等人的相关文章，第 2800 页（5）。
