Ito Eiji, Seki Yukio, Saito Kiyoshi, Saito Ryuta
Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-Ku, Nagoya, Aichi, 466-8560, Japan.
Department of Neurosurgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Aichi, Japan.
Acta Neurochir (Wien). 2023 Apr;165(4):959-965. doi: 10.1007/s00701-022-05434-0. Epub 2022 Dec 2.
The pathophysiology of neurovascular compression syndrome has not been fully elucidated, and cerebrospinal fluid levels of nerve tissue-related markers involved in this disorder have not yet been reported.
We measured cerebrospinal fluid levels of S100B protein, neuron-specific enolase, and myelin basic protein in 21 patients with trigeminal neuralgia, 9 patients with hemifacial spasms, and 10 patients with non-ruptured intracranial aneurysms (control). Cerebrospinal fluid levels of these markers were determined using commercially available assay kits.
Both trigeminal neuralgia and hemifacial spasm groups showed significantly increased cerebrospinal fluid levels of S100B compared with the control group (1120 [IQR 391-1420], 766 [IQR 583-1500], and 255 [IQR 190-285] pg/mL, respectively; p = 0.001). There were no statistically significant differences in cerebrospinal fluid levels of neuron-specific enolase or myelin basic protein among the groups.
Cerebrospinal fluid S100B levels were significantly higher in patients with trigeminal neuralgia and hemifacial spasm than in controls, which suggests the involvement of S100B in the underlying pathophysiology of neurovascular compression syndrome.
神经血管压迫综合征的病理生理学尚未完全阐明，且尚未有关于该疾病中涉及的神经组织相关标志物的脑脊液水平的报道。
我们测量了21例三叉神经痛患者、9例面肌痉挛患者和10例未破裂颅内动脉瘤患者（对照组）的脑脊液中S100B蛋白、神经元特异性烯醇化酶和髓鞘碱性蛋白的水平。使用市售检测试剂盒测定这些标志物的脑脊液水平。
与对照组相比，三叉神经痛组和面肌痉挛组的脑脊液S100B水平均显著升高（分别为1120[四分位间距391 - 1420]、766[四分位间距583 - 1500]和255[四分位间距190 - 285]pg/mL；p = 0.001）。各组间神经元特异性烯醇化酶或髓鞘碱性蛋白的脑脊液水平无统计学显著差异。
三叉神经痛和面肌痉挛患者的脑脊液S100B水平显著高于对照组，这表明S100B参与了神经血管压迫综合征的潜在病理生理学过程。
