Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Braz J Cardiovasc Surg. 2023 Apr 23;38(2):305-308. doi: 10.21470/1678-9741-2022-0002.
Dexmedetomidine has been subjected to an extensive evaluation for its' role in the prevention of postoperative delirium following cardiac surgery. In striking contrast to the preexisting meta-analysis supporting postoperative delirium-reduction with dexmedetomidine, few recently concluded multicentric large scale randomized controlled trials suggest otherwise. This article aims to present a nuanced perspective of the evolving controversy by attempting to decode the apparent incongruences in the literature accumulating off-late, which is particularly pertinent amidst an ever-escalating heterogeneity in the current research ecosystem.
右美托咪定在心脏手术后预防术后谵妄方面的作用已经得到了广泛的评估。与先前支持使用右美托咪定减少术后谵妄的荟萃分析形成鲜明对比的是，最近几项结论性的多中心大规模随机对照试验表明并非如此。本文旨在通过试图解读最近积累的文献中明显的不一致之处，呈现出这一争议的细微差别，这在当前研究生态系统中日益增加的异质性中尤为重要。
